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Orb/CPEB-related RNA-binding protein

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GeneName Zorba
Aliases ENSDARG:ENSDARG00000008454; fd15c06, wu:fd15c06
Description Orb/CPEB-related RNA-binding protein
GenomicLocation chromosome 7 49697695-49708223 reverse strand
ExternalIDs ZFIN:ZDB-GENE-990927-1; Entrez:30702; UniGene:75838
TranscriptID ENSDART:ENSDART00000098904; ENSDART:ENSDART00000127007; ENSDART:ENSDART00000024062
mRNA NCBI:NM_131427
GeneDescription Zorba transcribes some of the earliest mRNAs which localizes at the animal pole at stage III of oogenesis. The mRNAs become reistricted to the tight subcortical crescent at stage III of oogenesis.
GeneFunction Bally-Cuif et al. (1998), stated that the zorba gene encodes a protein of 600 amino acids which shows significant homology to Drosophila Orb (40% overall identity) and XenopusCPEB, and the recently identified mouse CPEB (67% overall identity). They found that the distribution of zorba mRNA and protein was biphasic during oocyte maturation. An initial phase of ubiquitous distribution until stage II is followed by a phase of sharp localization from stage III onwards. The initial ubiquitous phase of zorba expression might correspond to a general role in oocyte development, via the translational regulation of mRNAs necessary for oocytes survival or maturation. Zorba transcribes some of the earliest mRNAs which localizes at the animal pole at stage III of oogenesis. The mRNAs become reistricted to the tight subcortical crescent at stage III of oogenesis.Kosaka et al. (2007), stated that zor1/zorba mRNA unlike other mRNA remains localized to the vegetative pole while in contrast RNA from vasa, nanos1 and dazl co-localize with the mitochondrial cloud.Ferg et al. (2007), stated that Zorba is a maternally expressed gene and is upregulated 2.51-fold in TBP MO embryos. They found high levels of zorba expression in fertilized wild-type eggs and early embryos before MBT, followed by a sharp decrease soon after the MBT, followed by a slight increase at the dome stage. In contrast, in TBP morphant embryos, zorba mRNA levels showed similar levels throughout early development, consistent with the assumption that degradation of maternal mRNA was impaired. Expression of recombinant TBP resulted in increase of degradation of zorba. Thisse et al. (2004), gave the expression pattern of zorba in developing zebrafish embryos. From stages 14 -19 somites expressed is observed in primordial germ cells and in notochord. From 20-25 somites to Prim-5 and from Prim-15 to Prim-25 stage expression is seen in primordial germ cells and in notochord. From High-pec to Long-pec expression is observed in primordial germ cells and retina. At 5 dpf expression is clearly visible in retina and in small hindbrain nuclei.
GeneCloning Zorba is Contained in a BAC clone CH211-231O17 (Vector: pTARBAC2.1).
GeneStructure This gene encodes for 3 transcripts.The transcript ENSDART00000024062 consists of 5 exons and is 663 bps in length. The protein product ENSDARP00000028099 consists of 210 residues.The transcript ENSDART00000098904 consists of 12 exons and is 2.912 bps in length. The protein product ENSDARP00000089674 consists of 559 residues.The transcript ENSDART00000127007 consists of 13 exons and is 1.840 bps in length. The protein product ENSDARP00000109570 consists of 601 residues
Protein ENSDARP00000089674 ENSDARP00000109570 ENSDARP00000028099
ProteinDomainandFamilies has domain InterPro:IPR000504;
Motifs has motif Prosite:PS50102
Expression ArrayExpress:ENSDARG00000008454
GeneOntology GO:0003723GO:0046872GO:0003676GO:0000166GO:0006397GO:0006417GO:0005737
Orthologs Entrez: 64506;
VariationAndRepeats RSID:rs41024725; RSID:rs41132648; RSID:rs40774679; RSID:rs40655837; RSID:rs40648770; RSID:rs3728092; RSID:rs40654130;

RelatedPubMedArticles Bally-Cuif, L., Schatz, W.J., and Ho, R.K. (1998); Characterization of the zebrafish Orb/CPEB-related RNA-binding protein and localization of maternal components in the zebrafish oocytes; Mech. Dev. 77:31-47. PMID:9784598 . Ferg, M., Sanges, R., Gehrig, J., Kiss, J., Bauer, M., Lovas, A., Szabo, M., Yang, L., Straehle, U., Pankratz, M.J., Olasz, F., Stupka, E., and Müller, F. (2007); The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. EMBO J. 26(17):3945-3956. PMID:17703193 . Kosaka, K., Kawakami, K., Sakamoto, H., and Inoue, K. (2007); Spatiotemporal localization of germplasm RNAs during zebrafish oogenesis; Mech. Dev. 124(4):279-289. PMID:17293094 .Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - AravindR
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