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wingless-type MMTV integration site family, member 11, related

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GeneName wnt11r
Aliases ENSDARG:ENSDARG00000014796; wu:fk73h04; wnt11r
Description wingless-type MMTV integration site family, member 11, related
GenomicLocation chromosome 10 33059096-33077995 forward strand
ExternalIDs Entrez:30283; EMBL:BC066498; UniGene:76466; ZFIN:ZDB-GENE-980526-249;
TranscriptID ENSDART:ENSDART00000099880
mRNA NCBI:NM_131076
GeneDescription Wnt11 is a secreted protein that signals through the non-canonical planar cell polarity pathway and is a potent modulator of cell behavior and movement. Wnt11r is the ortholog of the mammalian wnt11 gene and has been identified first in Xenopus genome.
GeneFunction Matsui T et al. (2005) showed that several components of noncanonical Wnt signaling pathways are involved in the control of convergence and extension (CE) movements during zebrafish and Xenopus gastrulation. One of these components was shown to be wnt11r gene which acts along with along with three other Wnt noncanonical ligands wnt4a, silberblick/wnt11 and wnt11-related . These genes regulate this process by acting in a largely redundant way.
GeneCloning it is contained in BAC clone [BAC] DKEY-250D21
GeneStructure The gene encodes for a single transcript. The transcript ENSDART00000099880 consists of 6 exons and is 2171bps in length. The protein product ENSDARP00000090653 consists of 352 residues.
Protein ENSDARP00000090653
ProteinDomainandFamilies has domain "InterPro:IPR005817; InterPro:IPR018161; InterPro:IPR026536;
Motifs has motif Prosite:PS00246; PFAM:PF00110; PRINTS:PR01349;
Expression ArrayExpress:ENSDARG00000014796;
GeneOntology GO:0005109;GO:0005102;GO:0016055;GO:0045165;GO:0030182;GO:0016055;GO:0007275;GO:0007507;GO:0001947;GO:0042074;GO:0005615;GO:0005576;GO:0005578;
Orthologs Entrez:7481;

DisordersAndMutations The antisense morpholino oligonucleotides directed against the gene Wnt11r has the following sequence - wnt11r-MO, 5-AGGGAAGGTTCGCTTCATGCTGTAC-3 and wnt11r(2)- MO, 5-AAGATCCAGAAGACACTGATGCAGG-3. ZFINID:ZDB-GENO-080606-269;ZFINID:ZDB-GENO-061129-10;ZFINID:ZDB-GENO-110722-33;ZFINID:ZDB-GENO-091112-4;ZFINID:ZDB-GENO-091027-7;ZFINID:ZDB-GENO-130508-3;
RelatedPubMedArticles Matsui, T; Raya, A; Kawakami, Y; Callol-Massot, C; Capdevila, J; Rodríguez-Esteban, C; Izpisúa Belmonte, JC. (2005). Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 19(1):164-75. PMID:15630025 .Garriock, RJ; D'Agostino, SL; Pilcher, KC; Krieg, PA. (2005). Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev Biol. 279(1):179-92. PMID:15708567 .Garriock, RJ; Warkman, AS; Meadows, SM; D'Agostino, S; Krieg, PA. (2007). Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16. Dev Dyn. 236(5):1249-58. PMID:17436276 .Hardy, KM; Garriock, RJ; Yatskievych, TA; D'Agostino, SL; Antin, PB; Krieg, PA. (2008). Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol. 320(2):391-401. PMID:18602094 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-07-27 - PrernaBudakoti
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