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tripartite motif-containing 33

tripartite motif-containing 33


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GeneName tripartite motif-containing 33
Aliases ENSDARG:ENSDARG00000016181; wu:fc17f10, tif1 gamma, zgc:136680, mon, vampire, id:ibd2175, cb1085 , moonshine
Description tripartite motif-containing 33
GenomicLocation chromosome 8 11702090-11750361 forward strand
ExternalIDs Entrez:324053; EMBL:AY598453; UniGene:80165; ZFIN:ZDB-GENE-030131-2773;
TranscriptID ENSDART:ENSDART00000020116; ENSDART:ENSDART00000111005; ENSDART:ENSDART00000139603
mRNA NCBI:NM_001002871
GeneDescription mon gene as the zebrafish ortholog of mammalian transcriptional intermediary factor 1c (TIF1c), a member of the TIF1 family of transcriptional coactivators and corepressors (Le Douarin et al. 1995; Friedman et al. 1996; Kim et al. 1996; Venturini et al. 1999; Peng et al. 2002). The three members of the vertebrate TIF1 family (a, b, and c) are large nuclear proteins that each contain an N-terminal RBCC or TRIM domain (Reymond et al. 2001) composed of a RING finger, two B-boxes, and a coiled-coil domain.
GeneFunction Sumanas et al. (2005) during this study they reported that blf expression was almost completely absent in ¨1/4 of the progeny (4 out of 15 embryos) from montu244b heterozygous carriers Ramson et al. (2004) reported that mon encodes the zebrafish ortholog of mammalian transcriptional intermediary factor 1c (TIF1c) (or TRIM33), a member of the TIF1 family of coactivators and corepressors. They have also determined that mutations in the mon gene cause a disruption in both primitive embryonic and de finitive adult hematopoiesis, resulting in a severe loss of erythroid cells. Erythroid progenitor cells in mon mutants are initially present, but fail to express normal levels of hematopoietic transcription factors and undergo apoptosis.Ramson et al. (1996) have identified moonshine hematopoiesis mutant as part of a large scale chemical mutagenesis screen of the zebrafish (Danio rerio) genome. They have reported 7 stronger alleles of moonshine (mon), including montb222b and montc246b, are the only mutations among the 33 that can be classified as bloodless at the onset of circulation. All of the mutant mon alleles are recessive, cause severe anemia and are lethal after 5 to 7 days except for montc239b.van Eeden et al. 1996 during large scale chemical mutagenesis screen of the zebrafish affecting larval fin formation, they have observe that fin folds of moonshine (mon) mutants also have irregular edges.
GeneCloning The gene is contained in BAC clone DKEYP-46C9 (Vector: pIndigoBAC-536). trim33 Encodes: [EST] cb1085,fc17f10, ibd2175. [cDNA] MGC:136680.
GeneStructure The gene encodes for 3 transcripts. The transcript (ENSDART00000020116) consists of 20 exons and is 4048 bps in length. The protein product (ENSDARP00000025140) is of 1176 residues long. The transcript (ENSDART00000111005) comprises of 20 coding exons out of 21 exons with a length of 3903 bps and codes for the protein (ENSDARP00000100207) of 1508 residues. The third transcript (ENSDART00000139603) has 2 exons and is of 819 bps in length and codes for protein (ENSDARP00000113637) of 104 residues in length.
Protein ENSDARP00000025140 ENSDARP00000100207 ENSDARP00000113637
ProteinDomainandFamilies has domain InterPro:IPR001487; InterPro:IPR003649; InterPro:IPR001841; InterPro:IPR013083; InterPro:IPR000315; InterPro:IPR001965;
Motifs has motif Prosite:PS00518; Prosite:PS01359; PFAM:PF00439; PFAM:PF00628; PFAM:PF00643; PRINTS:PR00503; PRINTS:PR01406; UniProt:TRI33_DANRE;
Expression ArrayExpress:ENSDARG00000016181
GeneOntology GO:0005622; GO:0006355; GO:0035162; GO:0035166; GO:0005515; GO:0008270;
Orthologs Entrez: [Gene:51592]
VariationAndRepeats RSID:rs41119946; RSID:rs40974009
DisordersAndMutations Moonshine is an ENU mutant. Embryos of this mutant are bloodless at the onset of circulation. After 4 days of development there are 50 to 100 blood cells in circulation. Fin edges are jagged but not necrotic. Iridophores are increased in number and migrate abnormally into the tail fin. Also described in Kelsh et al. (1995). Relative allele strengths: tb222b, te345, tg234, tu244b, ty57, tz276, > tc246b > tc239b
RelatedPubMedArticles Sumanas S, Zhang B, Dai R, Lin S. 15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation. Dev Biol. 2005 Jul 1;283(1):85-96. PMID:15890328 .
Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug;2(8):E237. Epub 2004 Aug 17. PMID:15314655 .
Davidson AJ, Zon LI. The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene. 2004 Sep 20;23(43):7233-46. Review. PMID:15378083 .
Bahary N, Zon LI. Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998;16 Suppl 2:67-78. Review. PMID:11012178 .
Ransom DG, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh RN, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Mullins MC, Nüsslein-Volhard C. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996 Dec;123:311-9. PMID:9007251 .
Weinstein BM, Schier AF, Abdelilah S, Malicki J, Solnica-Krezel L, Stemple DL, Stainier DY, Zwartkruis F, Driever W, Fishman MC. Hematopoietic mutations in the zebrafish. Development. 1996 Dec;123:303-9. PMID:9007250 .
van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Warga RM, Nüsslein-Volhard C. Genetic analysis of fin formation in the zebrafish, Danio rerio. Development. 1996 Dec;123:255-62. PMID:9007245 .
Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P, Odenthal J, Mullins MC, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Kane DA, Warga RM, Beuchle D, Vogelsang L, Nüsslein-Volhard C. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996 Dec;123:369-89. PMID:9007256 .
NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-20 - ShrutiKapur
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