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tll1

tolloid-like 1

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GeneInformationForm
GeneName tll1
Aliases ENSDARG:ENSDARG00000037429; tld; tolloid; tll1
Description tolloid-like 1
GenomicLocation chromosome 1 19514406-19607327 reverse strand
ExternalIDs Entrez:474335; EMBL:AF027596; UniGene:75803; ZFIN:ZDB-GENE-041020-1;
TranscriptID ENSDART:ENSDART00000054472
mRNA NCBI:NM_131010
GeneDescription Tolloid is a metalloprotease that can eliminate the activity of BMP antagonist chordin.
GeneFunction Connors et al. (1999) generated a tolloid transgene under the control of the inducible hsp70 promoter and demonstrated the role of tolloid (mfn) in completion of gastrulation. Chimeric studies indicate the requirement of tld for ventral (posterior)tail bud expression. The dorsal (anterior) tail bud expression domain of tld lies in closer proximity to chd expressing cells in the tail bud. Using the heatshock-inducible tld transgene, they revealed the function of chd in tail patterning both during and after gastrulation. Thus, fine modulation of BMP signaling levels through the negative and positive actions of Chordin and Tolloid, respectively, patterns tail tissues.Herpin et al. (2007) cloned a gene encoding a tolloid homologue from the bivalve mollusk Crassostrea gigas. They determined the intron-exons structure of the gene encoding C.gigas tolloid and have compared it with those of homologous genes from both protostomes and deuterostomes. They analyzed the functionality of oyster tolloid in zebrafish embryo and showed the ventralization of zebrafish embryos at 24 h post fertilization, when the protein is overexpressed.
GeneCloning tll1 contained in BAC: CH211-198G9, BAC:DKEY-285B2 ; encodes [cDNA] MGC:195104, MGC:195127.
GeneStructure Tll1 encodes a single transcript, ENSDART00000054472 which consists of 22 exons with 21 coding exons and 4633 bps. The protein product ENSDARP00000054471 consists of 1022 residues.
Protein ENSDARP00000054471
ProteinDomainandFamilies has domain InterPro:IPR000859; InterPro:IPR006025; InterPro:IPR013032; InterPro:IPR000152; InterPro:IPR006026; InterPro:IPR001506; InterPro:IPR013091; InterPro:IPR001881; InterPro:IPR006209; InterPro:IPR000742; InterPro:IPR015446;
Motifs has motif Prosite:PS00010; Prosite:PS00142; Prosite:PS01186; Prosite:PS01187; PFAM:PF00008; PFAM:PF00431; PFAM:PF01400; PFAM:PF07645; PRINTS:PR00480; UniProt:TLL1_DANRE;
Expression ArrayExpress:ENSDARG00000037429
GeneOntology GO:0005786; GO:0005576; GO:0006508; GO:0009953; GO:0035162; GO:0048264; GO:0030513; GO:0035124; GO:0006829; GO:0006816; GO:0009968; GO:0045045; GO:0001568; GO:0001885; GO:0001707; GO:0008270; GO:0008237; GO:0008533; GO:0005509; GO:0008233; GO:0004866; GO:0005262; GO:0019855; GO:0008191; GO:0016787; GO:0046872;
Orthologs Entrez:[Gene:7092]
VariationAndRepeats RSID:rs179542419; RSID:rs179542333; RSID:rs179542227; RSID:rs179542250; RSID:rs179542418; RSID:rs179542188; RSID:rs179542260; RSID:rs180014283; RSID:rs179542186; RSID:rs179542175; RSID:rs179542210; RSID:rs179542406; RSID:rs179542357; RSID:rs179542239; RSID:rs179542448; RSID:rs179542397; RSID:rs179542247; RSID:rs180014295; RSID:rs180014280; RSID:rs40875481; RSID:rs180014288; RSID:rs180014273; RSID:rs180014294; RSID:rs180014321; RSID:rs180014332; RSID:rs180014302; RSID:rs180014313; RSID:rs41227122; RSID:rs41048244; RSID:rs40695588; RSID:rs40682825; RSID:rs40864650; RSID:rs41001831; RSID:rs180014311; RSID:rs180014278; RSID:rs180014324; RSID:rs180014304; RSID:rs40949573; RSID:rs40793800; RSID:rs180014299; RSID:rs180014323; RSID:rs180014286; RSID:rs180014314; RSID:rs41163318; RSID:rs40908967; RSID:rs41024500; RSID:rs41028584; RSID:rs41153295; RSID:rs40866456; RSID:rs41024273; RSID:rs40926519; RSID:rs40910828; RSID:rs40991518; RSID:rs180014287; RSID:rs41234091; RSID:rs40836148; RSID:rs41013159; RSID:rs40913877; RSID:rs40710714; RSID:rs40924446; RSID:rs180014310; RSID:rs40911953; RSID:rs40776654; RSID:rs40925626; RSID:rs41067718; RSID:rs180014290; RSID:rs180014292; RSID:rs180014330; RSID:rs180014301; RSID:rs180014312; RSID:rs180014279; RSID:rs180014309; RSID:rs180014276; RSID:rs180014317; RSID:rs40992811; RSID:rs40836051; RSID:rs40728203; RSID:rs40885203; RSID:rs41094099; RSID:rs40831467; RSID:rs41194154; RSID:rs40707598; RSID:rs180014293; RSID:rs41088511; RSID:rs41108029; RSID:rs180014285; RSID:rs40943224; RSID:rs40773973; RSID:rs41239877; RSID:rs40712420; RSID:rs41180912; RSID:rs41219987; RSID:rs180014307; RSID:rs180014275; RSID:rs180014316; RSID:rs180014300; RSID:rs180014327; RSID:rs180014322; RSID:rs180014325; RSID:rs180014305; RSID:rs180014297; RSID:rs180014291; RSID:rs180014281; RSID:rs180014282; RSID:rs180014319; RSID:rs180014329; RSID:rs180014298; RSID:rs180014326; RSID:rs180014277; RSID:rs180014308; RSID:rs180014274; RSID:rs180014315; RSID:rs180014284; RSID:rs180014303; RSID:rs180014289; RSID:rs180014318; RSID:rs40710016; RSID:rs40683440; RSID:rs40993718; RSID:rs40940426; RSID:rs41010157; RSID:rs40673619; RSID:rs40803778; RSID:rs41154723; RSID:rs40809208; RSID:rs41094817; RSID:rs40688256; RSID:rs40764509; RSID:rs41091166; RSID:rs41187773; RSID:rs40961384; RSID:rs179748036; RSID:rs179747865; RSID:rs179748214; RSID:rs179747948; RSID:rs179748013; RSID:rs179747852; RSID:rs179748037; RSID:rs179748227; RSID:rs179748205; RSID:rs179747988; RSID:rs179748170; RSID:rs179748159; RSID:rs40722777; RSID:rs40823443; RSID:rs41083028; RSID:rs40742136; RSID:rs40684671; RSID:rs40736792; RSID:rs40976590; RSID:rs40721333; RSID:rs41242592; RSID:rs41031482; RSID:rs40851782; RSID:rs41029810; RSID:rs41020648; RSID:rs40731039; RSID:rs41219209; RSID:rs40840937; RSID:rs41055989; RSID:rs40714828; RSID:rs40897263; RSID:rs40974939; RSID:rs40633510; RSID:rs41200262; RSID:rs41091010; RSID:rs40939289; RSID:rs40860561; RSID:rs40888392; RSID:rs179748042; RSID:rs179747866; RSID:rs179747952; RSID:rs179747932; RSID:rs179748217; RSID:rs179747963; RSID:rs179747888; RSID:rs40921057; RSID:rs41122467; RSID:rs41112159; RSID:rs40849703; RSID:rs41135179; RSID:rs40982942; RSID:rs40914922; RSID:rs40777446; RSID:rs41173792; RSID:rs40901270; RSID:rs40782094; RSID:rs41077043; RSID:rs40823086; RSID:rs40769639; RSID:rs41152605; RSID:rs179748069; RSID:rs179748215; RSID:rs179747851; RSID:rs179748241; RSID:rs179748026; RSID:rs179747933; RSID:rs179748022; RSID:rs179747861; RSID:rs179748167; RSID:rs179747951; RSID:rs179748102; RSID:rs179748176; RSID:rs179747877; RSID:rs40832183; RSID:rs40941829; RSID:rs179748220; RSID:rs40941573; RSID:rs40768366; RSID:rs40736462; RSID:rs40978165; RSID:rs40779292; RSID:rs40899467; RSID:rs40700339; RSID:rs41060676; RSID:rs40822340; RSID:rs179747903; RSID:rs179748032; RSID:rs179748133; RSID:rs179748141; RSID:rs179748074; RSID:rs179748109; RSID:rs179748235; RSID:rs179748174; RSID:rs179748053; RSID:rs179747987; RSID:rs179747871; RSID:rs179747962; RSID:rs179748101; RSID:rs179748158; RSID:rs179747986; RSID:rs40947226; RSID:rs41020891; RSID:rs41099591; RSID:rs40860515; RSID:rs40891645; RSID:rs41173311; RSID:rs40840962; RSID:rs40735628; RSID:rs40993085; RSID:rs179747901; RSID:rs179747916; RSID:rs40880179; RSID:rs179748210; RSID:rs179748057; RSID:rs40691953; RSID:rs41048881; RSID:rs179748054; RSID:rs179748189; RSID:rs179748226; RSID:rs179748204; RSID:rs179748010; RSID:rs179747860; RSID:rs179748254; RSID:rs179747927; RSID:rs179747958; RSID:rs179747938; RSID:rs179748067; RSID:rs179748099; RSID:rs179748129; RSID:rs179748114; RSID:rs179747990; RSID:rs40814396; RSID:rs179748124; RSID:rs179748157; RSID:rs179747911; RSID:rs40961864; RSID:rs179747964; RSID:rs40788729; RSID:rs40777983; RSID:rs179747947; RSID:rs41118241; RSID:rs179748135; RSID:rs179748239; RSID:rs179747984; RSID:rs40748885; RSID:rs41137981; RSID:rs40950918; RSID:rs40809148; RSID:rs41186345; RSID:rs40871622; RSID:rs40811125; RSID:rs40792494; RSID:rs40904845; RSID:rs41058900; RSID:rs179747974; RSID:rs179747908; RSID:rs179748145; RSID:rs179747920; RSID:rs179747854; RSID:rs179748039; RSID:rs179748065; RSID:rs179748063; RSID:rs179748160; RSID:rs179748031; RSID:rs179747867; RSID:rs179747946; RSID:rs179748203; RSID:rs179747978; RSID:rs179748163; RSID:rs41001568; RSID:rs40929806; RSID:rs41126935; RSID:rs41013478; RSID:rs40833782; RSID:rs40648316; RSID:rs40990509; RSID:rs179748052; RSID:rs179748185; RSID:rs179748087; RSID:rs179748118; RSID:rs179748151; RSID:rs179748078; RSID:rs179748035; RSID:rs179747873; RSID:rs179748001; RSID:rs40999342; RSID:rs40728834; RSID:rs40778493; RSID:rs41007399; RSID:rs40889487; RSID:rs40925802; RSID:rs179748045; RSID:rs179747879; RSID:rs179748004; RSID:rs179748238; RSID:rs179748137; RSID:rs179748191; RSID:rs179747884; RSID:rs179748190; RSID:rs179748202; RSID:rs179748165; RSID:rs40712263; RSID:rs41227886; RSID:rs179747881; RSID:rs179747913; RSID:rs40830140; RSID:rs40856919; RSID:rs40905020; RSID:rs41014952; RSID:rs40647806; RSID:rs40774783; RSID:rs41013804; RSID:rs41186377; RSID:rs179747902; RSID:rs179748243; RSID:rs179747915; RSID:rs179748125; RSID:rs179748108; RSID:rs179747956; RSID:rs179748196; RSID:rs179748094; RSID:rs179748253; RSID:rs179748181; RSID:rs179747967; RSID:rs40765804; RSID:rs41073509; RSID:rs179747892; RSID:rs179747991; RSID:rs179748207; RSID:rs179747900; RSID:rs179748178; RSID:rs179748192; RSID:rs41108234; RSID:rs179748183; RSID:rs179748213; RSID:rs179747891; RSID:rs179748020; RSID:rs179747847; RSID:rs179748246; RSID:rs179748097; RSID:rs179748122; RSID:rs179747945; RSID:rs179747981; RSID:rs179747917; RSID:rs179748005; RSID:rs179748029; RSID:rs41191453; RSID:rs41033671; RSID:rs41079217; RSID:rs40944418; RSID:rs41051316; RSID:rs40748205; RSID:rs40838114; RSID:rs41134155; RSID:rs41155129; RSID:rs41149976; RSID:rs41124012; RSID:rs40983338; RSID:rs40839814; RSID:rs40855966; RSID:rs40974773; RSID:rs40874862; RSID:rs40747581; RSID:rs40997084; RSID:rs41101203; RSID:rs40717956; RSID:rs40753556; RSID:rs40876035; RSID:rs40624768; RSID:rs179748089; RSID:rs41188361; RSID:rs179747960; RSID:rs179748018; RSID:rs41024164; RSID:rs41179380; RSID:rs41003730; RSID:rs40965479; RSID:rs179748179; RSID:rs179748206; RSID:rs179748077; RSID:rs179748110; RSID:rs179748138; RSID:rs179748201; RSID:rs179748240; RSID:rs179747899; RSID:rs179747928; RSID:rs179747982; RSID:rs179747912; RSID:rs179748143; RSID:rs179748084; RSID:rs179748060; RSID:rs179748152; RSID:rs179747918; RSID:rs179747953; RSID:rs179748216; RSID:rs179747849; RSID:rs41207280; RSID:rs41123470; RSID:rs179748252; RSID:rs40758655; RSID:rs40922064; RSID:rs40717442; RSID:rs41250306; RSID:rs41135566; RSID:rs40732891; RSID:rs40747931; RSID:rs40712324; RSID:rs41089671; RSID:rs41130174; RSID:rs41248187; RSID:rs40871875; RSID:rs40743251; RSID:rs40757353; RSID:rs41030489; RSID:rs40733979; RSID:rs40770501; RSID:rs40901931; RSID:rs40847204; RSID:rs40947473; RSID:rs41088403; RSID:rs179748092; RSID:rs179748076; RSID:rs179747970; RSID:rs179748079; RSID:rs179748148; RSID:rs179748244; RSID:rs179747853; RSID:rs179748033; RSID:rs41157810; RSID:rs40960966; RSID:rs40857603; RSID:rs41083361; RSID:rs40857486; RSID:rs41157310; RSID:rs41034715; RSID:rs41036716; RSID:rs40848642; RSID:rs40761907; RSID:rs179747961; RSID:rs179747941; RSID:rs179748085; RSID:rs179748149; RSID:rs41170520; RSID:rs179748062; RSID:rs179748055; RSID:rs179747944; RSID:rs40921859; RSID:rs41047498; RSID:rs179748127; RSID:rs40878752; RSID:rs41032905; RSID:rs41114693; RSID:rs40647697; RSID:rs41245391; RSID:rs40880032; RSID:rs41180633; RSID:rs40766683; RSID:rs41236742; RSID:rs40712564; RSID:rs40905769; RSID:rs40699671; RSID:rs179747975; RSID:rs179747904; RSID:rs40820874; RSID:rs40877765
DisordersAndMutations Blader et al. (1997) discovered the role of tld in cleaving chd invitro but not noggin or follistatin. It can also inhibit chd function in vivo through the mechanism by which tld increases BMP activity.Connors et al. (1999) injected tolloid mRNA into six dorsalized mutants out of which they rescued only one mutant, mini fin that was then demonstrated to encode tolloid gene. Minifin/tolloid activity is required for patterning ventral tissues of the tail: the ventral fin, the ventroposterior somites and vasculature, and is expressed throughout gastrulation in a ventral-animal domain, as well as dorsally and ventrally around the margin. In post-gastrula stages, it is expressed dorsally and ventrally in the tail bud with its dorsal limit of expression directly abutting chd expression.Jasuja et al. (2006) identified and mapped the zebrafish BMP1 gene. Knockdown analysis of BMP1 resulted in a mild tail phenotype, however, simultaneous knockdown of mini fin and bmp1 resulted in severe dorsalizaion resembling the swirl (swr) and snailhouse (snh) phenotypes. Thus they concluded bmp1 and mfn gene products that functionally overlap and are together responsible for a key portion of the chordin processing activity necessary to form zebrafish dorsoventral axis.
RelatedPubMedArticles Blader, P.; Rastegar, S.; Fischer, N.; Strähle, U.: Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid. Science. 1997 Dec 12;278(5345):1937-40. PMID:9395394 Connors, S. A.; Trout, J.; Ekker, M.; Mullins, M. C.: The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo. Development. 1999 Jun;126(14):3119-30. PMID:10375503 Connors, S. A.; Tucker, J. A.; Mullins, M. C.: Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues. Dev Biol. 2006 May 1;293(1):191-202. Epub 2006 Mar 10. PMID:16530746 Jasuja, R.; Voss, N.; Ge, G.; Hoffman, G. G.; Lyman-Gingerich, J.; Pelegri, F.; Greenspan, D. S.:bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech Dev. 2006 Jul;123(7):548-58. Epub 2006 May 25. PMID:16824737 Herpin, A.; Lelong, C.; Becker, T.; Favrel, P.; Cunningham, C.: A tolloid homologue from the Pacific oyster Crassostrea gigas. Gene Expr Patterns. 2007 Jun;7(6):700-708. Epub 2007 Mar 6. PMID:17433792 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-20 - ShrutiKapur
 
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