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T-box 24

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GeneName tbx24
Aliases ENSDARG:ENSDARG00000011785; tbx6r; z.TBX24; ZF-TBX24; id:ibd5070
Description T-box 24
GenomicLocation chromosome 12 4593057-4603583 forward strand
ExternalIDs Entrez:192294; EMBL:AB036516; UniGene:83300; ZFIN:ZDB-GENE-020416-5;
TranscriptID ENSDART:ENSDART00000013465
mRNA NCBI:NM_153666
GeneDescription Tbx24 belongs to T-box family of transcription factors that are defined by a conserved DNA binding domain called the T-box and regulate various aspects of embryogenesis by activating and/or repressing downstream genes.
GeneFunction Tbx24/fss are structurally related to mouse tbx6 and is expressed in the anterior PSM of the zebrafish embryo. Nikaido et al. (2002) suggested the role of tbx24 in transcriptional regulation of mesp-b locus in zebrafish.Kawamura et al. (2008) indicated the intrinsic transcriptional property of T-box proteins (tbx) to be controlled by Ripply family of proteins, which act as specific adaptors that recruit the global corepressor Groucho/TLE to T-box proteins.
GeneCloning Tbx24 is contained in [BAC] CH211-136M16, It also encodes [EST] eu421 , ibd507, [cDNA] MGC:194603
GeneStructure Tbx24 encodes a single transcript ENSDART00000013465 which consists 8 exons and is 3,049 bps in length.The protein product (ENSDARP00000015108) consists of 874 residues.
Protein ENSDARP00000015108
ProteinDomainandFamilies has domain InterPro:IPR001699; InterPro:IPR000194;
Motifs has motif Prosite:PS00152; Prosite:PS01283; PFAM:PF00907; PRINTS:PR00937; PRINTS:PR01217;
Expression ArrayExpress:ENSDARG00000011785;
GeneOntology GO:0005634; GO:0016469; GO:0015986; GO:0006355; GO:0009952; GO:0001756; GO:0021523; GO:0003700; GO:0046933; GO:0005524; GO:0046961;
Orthologs Entrez:Gene:6911
VariationAndRepeats RSID:rs41085409; RSID:rs41013739; RSID:rs41172383; RSID:rs41071868; RSID:rs41069934; RSID:rs41097011; RSID:rs40971506
DisordersAndMutations Nikaido et al. (2002) used gene-knockdown approach with morpholino antisense oligonucleotides to examine the function of tbx24 in somitogenesis. Segmentation of the presomitic mesoderm (PSM) was completely inhibited in embryos injected with tbx24 morpholinos, whereas the paraxial mesoderm in control embryos underwent normal segmentation. Their gene expression and phenotypic analyses in mutant embryos have implicated that Fss in somite formation is independent of notch signaling, suggesting the presence of a new pathway regulating somite boundary formation.Oates et al. (2005) found out that the paraxial mesoderm of fss/tbx24 mutants is not truly caudalized. Using cell transplantation together with confocal microscopy and fluorescent gene probes they characterized the fss/tbx24 phenotype. They also showed the role of fss/tbx24 for acquistition of rostral half-segment identity in a cell autonomous manner by analyzing mosaic embryos.Shaw et al. (2006) showed defective trunk angiogenic vessel patterning in fused-somites-like class of somite morphogenesis mutants in zebrafish. They also observed the vascular defects in bea mutants after the fourth somite, whereas all intersegmental vessels are affected in fss mutants. Failure to properly express repulsive vascular guidance cues in the somites of bea and fss mutant is responsible for the lack of proper patterning of angiogenic trunk intersegmental vessels.
RelatedPubMedArticles Nikaido, M.; Kawakami, A.; Sawada, A.; Furutani-Seiki, M.; Takeda, H.; Araki, K.: Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nat Genet. 2002 Jun;31(2):195-9. Epub 2002 May 20. PMID:12021786 Oates, A. C.; Rohde, L. A.; Ho, R. K.: Generation of segment polarity in the paraxial mesoderm of the zebrafish through a T-box-dependent inductive event. Dev Biol. 2005 Jul 1;283(1):204-14. PMID:15921674 Shaw, K. M.; Castranova, D. A.; Pham, V. N.; Kamei, M.; Kidd, K. R.; Lo, B. D.; Torres-Vasquez, J.; Ruby, A.; Weinstein, B. M.: fused-somites-like mutants exhibit defects in trunk vessel patterning. Dev Dyn. 2006 Jul;235(7):1753-60. PMID:16607654 Kawamura, A.; Koshida, S.; Takada, S.: Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators. Mol Cell Biol. 2008 May;28(10):3236-44. Epub 2008 Mar 10. PMID:18332117 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - ShrutiKapoor
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