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tbr1b

T-box, brain, 1b

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GeneInformationForm
GeneName tbr1b
Aliases tbr1, zf-tbr1
Description T-box, brain, 1b
GenomicLocation Chromosome 9: 52,776,692-52,782,926 reverse strand
ExternalIDs Ensembl:ENSDARG00000004712, Unigene ID Dr.10723,ZFIN:ZDB-GENE-000323-1
TranscriptID ENSDART00000006612; ENSDART00000125742
mRNA NM_001115090.2
GeneDescription This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes.
GeneFunction It modulates the frequency, rate or extent of cellular DNA-dependent transcription.
GeneCloning tbr1b Contained in: [Fosmid] CH1073-192A6
GeneStructure The gene codes for 2 transcripts.It cocnsits of 6 exons and the transcript (ENSDART00000006612) has a length of 3855 bps and codes for a protein (ENSDARP00000019930) of 676 aa residues. The other transcript (ENSDART00000125742) consists of 7 exons with a transcript length of 2203 and codes for a protein of 437 aa residue.
Protein ENSDARP00000019930; ENSDARP00000105823
ProteinDomainandFamilies has domain [InterPro:IPR001699]; [InterPro:IPR008967]; [InterPro:IPR018186]
Motifs has motif [PROSITE:PS50252] ; [PROSITE:PS01283]; [PROSITE:PS01264]; [Pfam:PF00907 ]
Expression Arrar |Express ENSDARG00000004712
GeneOntology GO:0006355
Orthologs Entrez: [Gene:10716]
VariationAndRepeats RSID:rs180033685; RSID:rs41008120; RSID:rs41008120; RSID:rs180033694
DisordersAndMutations

RelatedPubMedArticles Mione, M., Shanmugalingam, S., Kimelman, D., and Griffin, K. (2001) Overlapping expression of zebrafish T-brain-1 and eomesodermin during forebrain development. Mech. Dev. 100(1):93-97 PubMed: 11118891NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - ShrutiKapoor
 
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