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slc6a4a

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A

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GeneInformationForm
GeneName slc6a4a
Aliases ENSDARG:ENSDARG00000061165; slc6a4a
Description solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A
GenomicLocation chromosome 15 27957909-27967386 reverse strand
ExternalIDs Entrez:664719;ZFIN:ZDB-GENE-060314-1;UniGene:39284;
TranscriptID ENSDART:ENSDART00000086902; ENSDART:ENSDART00000141436
mRNA NCBI:NM_001039972
GeneDescription This gene encodes for serotonin transporter.
GeneFunction Norton W.H.J et al.( 2008) compared and contrasted the expression of slc6a4a and slc6a4b.It was analysed that the cells in which 5HT is synthesized by tph1, slc6a4b is utilized for uptake and in those were 5HT is synthesized by tph2, slc6a4a is utilized.
GeneCloning The gene is contained in a BAC clone CH211-225B7 (Vector: pTARBAC2.1).
GeneStructure This gene encodes for 2 transcripts (ENSDART00000086902) which consists of 13 exons and is 2,166 bps in length.The protein product (ENSDARP00000081336) consists of 646 residues . (ENSDART00000141436) which consists of 2 exons and is 540 bps in length.
Protein ENSDARP00000081336
ProteinDomainandFamilies has domain InterPro:IPR000175;
Motifs Prosite:PS00610; Prosite:PS50267;
Expression ArrayExpress:ENSDARG00000061165;
GeneOntology GO:0016020; GO:0005887; GO:0006836; GO:0005328; GO:0015222;
Orthologs Entrez:6532;
VariationAndRepeats RSID:rs40739136; RSID:rs40676347
DisordersAndMutations ZFINID:ZDB-ALT-120806-11836;
RelatedPubMedArticles Norton, W.H.; Folchert, A.; Bally-Cuif, L.:Comparative analysis of serotonin receptor(HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain.The Jouranal of Comparative Neurology 511:521542 ,2008. PMID:18839395 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r4 - 2013-08-22 - SubburajK
 
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