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superkiller viralicidic activity 2-like 2


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GeneName Skiv2l2
Aliases ENSDARG:ENSDARG00000013457; zgc:63838; wu:fd11a05; skiv2l2
Description superkiller viralicidic activity 2-like 2
GenomicLocation chromosome 10 7220903-7289147 forward strand
ExternalIDs Entrez:406795; UniGene:75715; ZFIN:ZDB-GENE-040426-2854
TranscriptID ENSDART:ENSDART00000026244
mRNA NCBI:NM_214768
GeneDescription Skiv2l2 is closely related to Saccharomyces cerevisiae SKl2, a DEAD-box RNA helicase in a multiprotein nuclease complex.
GeneFunction Yang et al. (2006) detected skiv2l2 transcripts early in the four-cell stage and they found it throughout early embryogenesis. Skiv212 expression was stronger in the central nervous system than in the rest of the embryo after 16 hpf .It was also found to be restricted to pectoral fins, cranial neural crest, the medial and posterior parts of the tectum and cerebellum, and ciliary marginal zone of the retina at larval stages.
GeneCloning No data available
GeneStructure Skiv2l2 encodes a single transcript (ENSDART00000026244) which consists of 27 exons and is 3310 bps in length. The protein product (ENSDARP00000024380) consists of 1034 residues.
Protein ENSDARP:ENSDARP00000024380;
ProteinDomainandFamilies InterPro:IPR001650; InterPro:IPR011545; InterPro:IPR012961; InterPro:IPR014001; InterPro:IPR016438; InterPro:IPR025696; InterPro:IPR027417;
Motifs Prosite:PS51192; Prosite:PS51194; PFAM:PF00270; PFAM:PF00271; PFAM:PF08148; PFAM:PF13234; UniProtKB:Q6P7X6;
Expression ArrayExpress:ENSDARG00000013457
GeneOntology GO:0005524;GO:0008026; GO:0004386; GO:0016787; GO:0016818; GO:0003676; GO:0031101; GO:0051781; GO:0005575;
Orthologs Entrez:23517;
VariationAndRepeats RSID:rs180082715; RSID:rs180082761; RSID:rs180084019; RSID:rs41191718; RSID:rs41073382
DisordersAndMutations ZFINID:ZDB-GENO-070423-3;ZFINID:ZDB-GENO-070426-4;ZFINID:ZDB-GENO-100521-3;ZFINID:ZDB-GENO-071114-2;Yang et al. (2006) reported the identification of two mutants, earthaj23e1 and juliej24e1 from a melanocyte ablation screen. They found out that juliej24e1 mutation is a splice-site mutation in skiv2l2. From the in situ analysis of skiv2l2 mutants skiv2l2 suggestedto play a role of in regulating melanoblast proliferation during early stages of melanocyte regeneration.
RelatedPubMedArticles Yang, C. T.; Hindes, A. E.; Hultman, K. A.; Johnson, S. L.: Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish. PLoS Genet. ;3(6):e88, 2007. Epub 2007 Apr 17. PMID:17542649 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r4 - 2013-09-03 - SubburajK
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