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prospero-related homeobox gene 1


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GeneName prox1
Aliases ENSDARG:ENSDARG00000055158; zgc:111888; prox1
Description prospero-related homeobox gene 1
GenomicLocation chromosome 17 33028428-33071546 reverse strand
ExternalIDs Entrez:30679; EMBL:AF063018; UniGene:133153; ZFIN:ZDB-GENE-980526-397;
TranscriptID ENSDART:ENSDART00000077476; ENSDART:ENSDART00000061487
mRNA NCBI:NM_131405
GeneDescription prospero/prox genes code for proteins that contain an atypical homeodomain and a conserved prospero domain. It is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. (Pistochhi et al., 2008).
GeneFunction Glasgow et al.,1998 had shown prox1 to be highly conserved as compared to other vertebrates,with 84%, 83% and 82% amino acid identity to mouse, human and chicken. They had detected the expression of Prox 1 by whole-mount immunohistochemistry in 10-somite stage embryos in the ectoderm overlaying the eye buds which continued caudally to the region of the otic vesicle.They had further shown that by the 18-somite stage, the expression of prox 1 was prominent in the lens primordium, appeared in muscle pioneer cells of the first few somites, and maintained expression in the head ectoderm. By the 28 h a diverse set of tissues expressed Prox 1. Liu et al., 2003 had shown that Prox 1 physically interacts with Ff1 isoforms. They had further shown that Ff1b displayed the strongest physical interaction with Prox 1 The interaction strength of Prox 1 with Ff1a and Ff1b was about 15 and 28%. They had also reported that LXXLL motifs of Prox 1 and heptad 9 and Af2 core domains of Ff1 are essential for interaction. They further reported that Prox 1 is a corepressor of Ff1 in zebrafish embryos. Pistocchi et al., 2008 reported that prox1 is widely expressed in several districts of the Central Nervous System. They evidenced the expression of prox1 in a group of neurons which are located in the hypothalamus at level of the posterior tuberculum. They had further shown that Prox1 knock-down leads to severe loss of hypothalamic catecholaminergic neurons.
GeneCloning It is contained in [BAC] DKEY-5J3 ZFIN:ZDB-BAC-070608-175
GeneStructure It encodes for a single transcript ENSDART00000077476 which has 5 exons and transcript length of 300bps. The protein product ENSDARP00000071943 which has 739 residues
Protein ENSDARP00000071943 ENSDARP00000061486
ProteinDomainandFamilies has domain InterPro:IPR007738;
Motifs has motif PFAM:PF05044;
Expression ArrayExpress:ENSDARG00000055158;
GeneOntology GO:0005634; GO:0007275; GO:0045449; GO:0043433; GO:0030239; GO:0003677; GO:0030528;
Orthologs Entrez:5629
VariationAndRepeats RSID:rs180094912; RSID:rs179861446; RSID:rs40817288; RSID:rs180094913; RSID:rs180094914; RSID:rs180094915; RSID:rs180094916; RSID:rs179861447; RSID:rs180094917; RSID:rs180094918; RSID:rs40893416; RSID:rs40710173; RSID:rs40946377; RSID:rs41111021; RSID:rs179861444; RSID:rs180094919
DisordersAndMutations ZFIN:ZDB-ALT-130129-2432: ZFIN:ZDB-MRPHLNO-050225-3; ZFIN:ZDB-MRPHLNO-090507-3; ZFIN:ZDB-MRPHLNO-090507-3
RelatedPubMedArticles Glasgow, E.; Tomarev, S.I.: Restricted expression of the homeobox gene prox1 in developing zebrafish. Mechanisms of development 76: 174-178,1998. Liu, Y.; Gao, W.; Teh, H.; Tan, J.; Chan, W.: Prox 1 is a Novel Coregulator of Ffib and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium . Molecular and Cellular Biology. 7243-7255,2003. PMID:14517294 Pistocchi, A.; Gaudenzi, G.; Carra, S.; Bresciani, E.; Giacco, L. D.; Cotelli, F.: Crucial role of zebrafish prox1 in hypothalamic catecholaminergic neurons development. BMC .Developmental Biology. 8:27,2008 PMID:18331627 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-08-29 - SrishtiNanda
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