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phosphoglucomutase 1

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GeneName pgm1
Aliases ENSDARG:ENSDARG00000013561; zgc:63718
Description phosphoglucomutase 1
GenomicLocation chromosome 6 31702353-31717395 reverse strand
ExternalIDs Entrez:394000; EMBL:BC055219; UniGene:76039; ZFIN:ZDB-GENE-040426-1245;
TranscriptID ENSDART:ENSDART00000006417
mRNA NCBI:NM_201025
GeneDescription phosphoglucomutase 1 is a gene which mainly functions in glycolysis and gluconeogenesis by catalyzing the transfer of phosphate between the C1- and C6- position of glucose.
GeneFunction Thisse et al., (2004) studied the expression of pgm1 gene at various stages of the zebrafish development. From 1-4 and 10-13 somite stages the pgm gene is expressed in the notochord and the yolk syncytial layer (YSL) region. During the 20-25 somite stage to prim 5 stage the expression is in YSL, myotomes and in central nervous system marginal zone and similar expression pattern was found during prim 15 to prim 25 stages. From the high pec to long pec stage their was expression found in liver, myotomes and central nervous system. At 5 dpf the bulk of the expression was visualized in liver, brain and intestinal bulb.
GeneCloning Pgm1 is contained in BAC clone DKEY-148H10 (Vector: pIndigoBAC-536)
GeneStructure Pgm1 encodes for a single transcript ENSDART00000006417 which consists of 11 exon and is 2008 bps in length. The protein product ENSDARP00000006510 consists of 561 residues.
Protein ENSDARP00000006510
ProteinDomainandFamilies has domain InterPro:IPR005844; InterPro:IPR016055; InterPro:IPR005843; InterPro:IPR005846; InterPro:IPR005845; InterPro:IPR005841; InterPro:IPR016066;
Motifs has motif Prosite:PS00710; PFAM:PF00408; PFAM:PF02878; PFAM:PF02879; PFAM:PF02880; PRINTS:PR00509;
Expression ArrayExpress:ENSDARG00000013561;
GeneOntology GO:0005975; GO:0016868;
Orthologs Entrez:5236
VariationAndRepeats RSID:rs40630588; RSID:rs40630585; RSID:rs40631607; RSID:rs40631608; RSID:rs40677818; RSID:rs40630586; RSID:rs40678269; RSID:rs40677819; RSID:rs40678265; RSID:rs40631089; RSID:rs40677820; RSID:rs40677822; RSID:rs41178031; RSID:rs40774285; RSID:rs41170843; RSID:rs40896476; RSID:rs40891285; RSID:rs41247932; RSID:rs40975406; RSID:rs41179896; RSID:rs40631088; RSID:rs40678271; RSID:rs40631604; RSID:rs40793190; RSID:rs41099216; RSID:rs40849772
DisordersAndMutations ZFIN ID: ZDB-ALT-130411-4016
RelatedPubMedArticles Thisse, B., Thisse, C.. (2004), Fast Release Clones: A High Throughput Expression Analysis , ZFIN Direct Data Submission.Wendy PUTT, Jane H. IVES, Martine HOLLYOAKE, David A. HOPKINSON, David B. WHITEHOUSE and Yvonne H. EDWARDS , (1993) , Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon ,; Biochem. J. 296, 417-422 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-15 - RamcharanAngom
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