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Neurotrophic tyrosine kinase, receptor, type 1

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GeneName ntrk1
Aliases ENSDARG:ENSDARG00000004586; Trk, trka,ntrk1
Description Neurotrophic tyrosine kinase, receptor, type 1
GenomicLocation chromosome 16 48861089-48918945 reverse strand
ExternalIDs EntrezGene:30546; EMBL:S78348; UniGene:88619; ZFIN:ZDB-GENE-980526-118;
TranscriptID ENSDART:ENSDART00000128068; ENSDART:ENSDART00000128068; ENSDART:ENSDART00000027013; ENSDART:ENSDART00000027013; ENSDART:ENSDART00000125908; ENSDART:ENSDART00000125908
mRNA NCBI:XM_692154
GeneDescription This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
GeneFunction Catania et al. (2003) examined the expression of Trk proteins in the olfactory epithelium of adult zebrafish using immunohistochemistry. They found that TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive. They suggested that these results provided indirect evidence for a possible role of NGF-like molecules (i.e. neurotrophin-6 and neurotrophin-7) in the peripheral olfactory system of adult zebrafish, acting on TrkA-like receptor expressing crypt neurons. They reported that it remained to be established whether or not TrkA-like receptors and their ligands play a function in the neurogenesis or differentiation of these cells.
GeneCloning Ntrk1 is contained in the BAC clone named DKEY-45N22
GeneStructure The gene encodes three transcript. first transcript ENSDART00000128068 consist of 17 exones and is 2663 bps long. second trancript ENSDART00000027013 which consists of 13 exons and is 2251 bps in length. The protein product (ENSDARP00000018941) consists of 619 residues. third transcript ENSDART00000125908 consist of 15 exones and is 2202 bps in length. the protien ENSDARP00000108266 has 733 residues.
Protein ENSDARP00000106635 ENSDARP00000106635 ENSDARP00000018941 ENSDARP00000018941 ENSDARP00000108266 ENSDARP00000108266
ProteinDomainandFamilies has domain InterPro:IPR002011; InterPro:IPR008266; InterPro:IPR001245; InterPro:IPR017441; InterPro:IPR007110; InterPro:IPR000719; InterPro:IPR013098; InterPro:IPR003599;
Motifs has motif Prosite:PS00109; Prosite:PS00239; PFAM:PF00069; PFAM:PF07714; PRINTS:PR00109;
Expression ArrayExpress:ENSDARG00000004586;
GeneOntology GO:0016020; GO:0006468; GO:0007169; GO:0005524; GO:0004672; GO:0004714; GO:0004713;
Orthologs Entrez:4914;
VariationAndRepeats RSID:rs40934661: RSID:rs40934661: RSID:rs40934661: RSID:rs41037304: RSID:rs41037304: RSID:rs41037304: RSIDrs252366555: RSIDrs252366555: RSID:rs252366555: RSID:rs252366552: RSID:rs252366552: RSID:rs252366552: RSID:rs252366551: RSID:rs252366551: RSID:rs252366551

RelatedPubMedArticles Catania, S.; Germaną, A.; Laurą, R.; Gonzalez-Martinez, T.; Ciriaco, E.; Vega, J.A.:The crypt neurons in the olfactory epithelium of the adult zebrafish express TrkA-like immunoreactivity. Neurosci Lett. ;350(1):5-8, 2003. PMID:12962904 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-07-07 - RamcharanAngom
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