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nkx2.7

NK2 transcription factor related 7

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GeneInformationForm
GeneName nkx2.7
Aliases ENSDARG:ENSDARG00000021232; nk2.7, zgc:100762, nkx2-7
Description NK2 transcription factor related 7
GenomicLocation chromosome 8 52507261-52510351 forward strand
ExternalIDs Entrez:30694; UniGene:272; ZFIN:ZDB-GENE-990415-179;
TranscriptID ENSDART:ENSDART00000023639
mRNA NCBI:NM_131419
GeneDescription

GeneFunction Lee et al.,1996 reported the identification of a new tinman- related gene, nkx2.7. They observed that the preeminence of nkx2.7 expression in these embryonic lineages is consistent with a key role in cell fate determination, perhaps in part through the induction of nkx2.5 and nkx2.3. they suggested a coordinate role for the three tinman-related genes and nkx2.3 nkx2.7, nkx2 in the development of the heart and pharyngeal arches.
GeneCloning The gene is contained in BAC clone CH211-67O1 (Vector: pTARBAC2.1).
GeneStructure The gene encodes for one transcripts. The transcript ENSDART00000023639 consist of or two exons, the transcript is 1176 bps long and codes for a protein ENSDARP00000004716 of length 269 residues.
Protein ENSDARP00000004716
ProteinDomainandFamilies has domain InterPro:IPR012287; InterPro:IPR001356;
Motifs has motif Prosite:PS00027; PFAM:PF00046; PRINTS:PR00024; PRINTS:PR00031;
Expression ArrayExpress:ENSDARG00000021232;
GeneOntology GO:0005634; GO:0006355; GO:0045449; GO:0006350; GO:0006353; GO:0031564; GO:0003677; GO:0003700; GO:0043565;
Orthologs Entrez:137814;
VariationAndRepeats RSID:rs179370317
DisordersAndMutations ZFINID:ZDB-GENO-111213-3: ZFINID:ZDB-GENO-111213-11: ZFINID:ZDB-GENO-111213-12
RelatedPubMedArticles Lee, K.H., Xu, Q., and Breitbart, R.E. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol. 180(2): 722-731 (Journal), 1996, PMID:8954740 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-07-06 - RamcharanAngom
 
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