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nonspecific cytotoxic cell receptor protein 1

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GeneName nccrp1
Aliases ENSDARG:ENSDARG00000035326; Zgc:122987, NCCRP-1, wu:fb12f07, wu:fa93e02
Description nonspecific cytotoxic cell receptor protein 1
GenomicLocation chromosome 5 38450813-38454718 forward strand
ExternalIDs Entrez:30078; EMBL:BC107632; UniGene:76380; ZFIN:ZDB-GENE-000210-13;
TranscriptID ENSDART:ENSDART00000051186
mRNA NCBI:NM_130921
GeneDescription Nccrp1 is a hypothetical protein belonging to an F-box subfamily. It is a FBA domain-containing protein LOC342897. It functions in target cell recognition and activation of cytotoxicity. It may function as an antigen recognition molecule.
GeneFunction Jaso et al. (2002) found that nccrp1 provides an important function in target cell recognition & activation of cytotoxicity. They suggested that NCCRP-1 performs a crucial function in innate immunity in teleosts. Their data suggested that the zebrafish NCCRP-1 protein may function as an antigen recognition molecule & may participate in innate immunity in teleosts. They showed that it shares a significant level of identity with another group of proteins belonging to an F-box subfamily.
GeneCloning Nccrp1 is contained in the BAC clone named DKEY-85K8 (Library: Daniokey; Vector: pIndigoBAC-536)
GeneStructure The gene encodes one transcript.The transcript ENSDART00000051186 consists of 6 exons and is 1,718 bps in length. The protein product (ENSDARP00000051185) consists of 237 residues.
Protein ENSDARP00000051185
ProteinDomainandFamilies has domain InterPro:IPR007397;
Motifs has motif Prosite:PS51114; PFAM:PF04300;
Expression ArrayExpress:ENSDARG00000035326;
GeneOntology GO:0005575; GO:0030163; GO:0005515; GO:0004872;
Orthologs Entrez:342897;
VariationAndRepeats RSID:rs40968163: RSID:rs41103717: RSID:rs252292574: RSID:rs41203617

RelatedPubMedArticles Jaso-Friedmann, L.; Peterson, D,S,; Gonzalez, D.S.; Evans, D.L.: The antigen receptor (NCCRP-1) on catfish and zebrafish nonspecific cytotoxic cells belongs to a new gene family characterized by an F-box-associated domain. J Mol Evol. 2002 Mar;54(3):386-95. PMID:11847564 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-07-06 - RamcharanAngom
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