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LIM domain kinase 1


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GeneName Limk1
Aliases ENSDARG:ENSDARG00000063651; limk1
Description LIM domain kinase 1
GenomicLocation chromosome 15 206750-291711 forward strand
ExternalIDs Entrez:735292; ZFIN:ZDB-GENE-061212-3; UniGene:103272;
TranscriptID ENSDART:ENSDART00000093188;
mRNA NCBI:NM_001042691
GeneDescription Limk1 is a cytoplasmic tyrosine kinase which consist of a C-terminal kinase domain, an internal PDZ domain and two N-terminally positioned LIM domains. It is a maternally expressed gene.
GeneFunction Woods et al. (2005) performed comparative mapping of genes and identified Limk1 orthologous to that of human gene.Otte et al. (2007) made phylogenetic analysis,on limk1, which have been shown to regulate actin cytoskeleton reorganization. It was also reported that limk1 expression was viewed in the eye, the cerebellum,intestine,liver,somites and the hindbrain. It was also found in some head vasculature (dorsal aorta and metencephalic artery)
GeneCloning limk1 is contained in the BAC clone named CH211-257O19
GeneStructure The gene codes for a single transcript ENSDART00000093188 which has 16 exons and 2174 bps. The product ENSDARP00000087620 has 648 amino acid residues.
Protein ENSDARP00000087620
ProteinDomainandFamilies has domain InterPro:IPR000719; InterPro:IPR001781; InterPro:IPR001478; InterPro:IPR017442; InterPro:IPR001245; InterPro:IPR017441;
Motifs has motif Prosite:PS00107; Prosite:PS00478; Prosite:PS50106; Prosite:PS50011; PFAM:PF00069; PFAM:PF00412; PFAM:PF00595; PRINTS:PR00109;
Expression ArrayExpress:ENSDARG00000063651;
GeneOntology GO:0006468; GO:0005515; GO:0008270; GO:0005524; GO:0004672; GO:0004713; GO:0016301; GO:0046872; GO:0000166;
Orthologs Entrez:3984;
VariationAndRepeats RSID:rs180164819; RSID:rs41047142; RSID:rs40848742; RSID:rs40631835; RSID:rs41023557; RSID:rs40779904; RSID:rs180105761; RSID:rs180164818; RSID:rs40652927; RSID:rs40652411; RSID:rs40652412; RSID:rs180164817; RSID:rs40865450; RSID:rs41081692; RSID:rs40751844; RSID:rs40815576; RSID:rs40802229; RSID:rs40826313; RSID:rs40818206; RSID:rs40709718; RSID:rs40689522; RSID:rs180164816; RSID:rs40651910; RSID:rs40652407; RSID:rs40652926; RSID:rs40651911; RSID:rs40902595; RSID:rs41147414; RSID:rs40758494; RSID:rs41241068; RSID:rs41182323; RSID:rs41054266; RSID:rs40760744; RSID:rs41118905; RSID:rs41063806; RSID:rs40771939; RSID:rs40714864; RSID:rs40892159; RSID:rs41197974; RSID:rs40652413; RSID:rs41079377; RSID:rs40826179; RSID:rs40997212; RSID:rs41136244; RSID:rs41087798; RSID:rs41003444; RSID:rs40908623; RSID:rs40943892; RSID:rs41116153; RSID:rs40721977; RSID:rs40878982; RSID:rs41023720; RSID:rs40991291; RSID:rs40799959; RSID:rs41128208; RSID:rs40850475; RSID:rs40700212; RSID:rs40777637; RSID:rs41221658; RSID:rs40712865; RSID:rs41175442; RSID:rs41026639; RSID:rs41221900; RSID:rs41050888; RSID:rs40655022; RSID:rs41041659; RSID:rs40679586; RSID:rs40764652; RSID:rs40834260; RSID:rs180164811; RSID:rs40686476; RSID:rs41123314; RSID:rs40849730; RSID:rs41075007; RSID:rs40716309; RSID:rs41119725; RSID:rs40912065; RSID:rs40693204; RSID:rs41188679; RSID:rs41042741; RSID:rs40737781; RSID:rs41016594; RSID:rs40669274; RSID:rs41047041; RSID:rs41146179; RSID:rs40746541; RSID:rs41190569; RSID:rs40716395; RSID:rs40996259; RSID:rs40921459; RSID:rs41134379; RSID:rs41223805; RSID:rs40913395; RSID:rs41239882; RSID:rs41016451; RSID:rs40726307; RSID:rs40858102; RSID:rs41028079; RSID:rs40803205; RSID:rs40980076; RSID:rs41080563; RSID:rs40695168; RSID:rs40917954; RSID:rs41133731; RSID:rs41147930; RSID:rs41224578; RSID:rs40666006; RSID:rs40836897; RSID:rs40652404; RSID:rs40652408; RSID:rs40652405; RSID:rs40651913; RSID:rs40652410; RSID:rs40652928; RSID:rs41150940; RSID:rs40956883; RSID:rs41078494; RSID:rs41075725; RSID:rs40869960; RSID:rs40778375; RSID:rs40914487; RSID:rs40860023; RSID:rs40959763; RSID:rs41152993; RSID:rs40789472; RSID:rs40944915; RSID:rs41047706; RSID:rs40873614; RSID:rs40969445; RSID:rs41038087; RSID:rs40950447; RSID:rs40818469; RSID:rs41004807; RSID:rs40618904; RSID:rs40652409

RelatedPubMedArticles Woods, I.G.; Wilson, C.; Friedlander, B.; Chang, P.; Reyes, D.K.; Nix, R.; Kelly, P.D.; Chu, F.; Postlethwait, J.H.; Talbot, W.S.: The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Res.;15(9):1307-14, 2005. PMID:16109975 Ott, E.B.; Te, Velthuis, A.J.; Bagowski, C.P.: Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development. Gene Expr Patterns.;7(5):620-9, 2007. PMID:17300993 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-20 - SrishtiNanda
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