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lbr

lamin B receoptor

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GeneInformationForm
GeneName lbr
Aliases ENSDARG:ENSDARG00000014013; sb:cb406; zgc:86649; wu:fc47b04; wu:fd36b07
Description lamin B receoptor
GenomicLocation chromosome 20 36420271-36441530 reverse strand
ExternalIDs Entrez:368360; EMBL:BC075756; UniGene:21958; ZFIN:ZDB-GENE-030804-11;
TranscriptID ENSDART:ENSDART00000019145; ENSDART:ENSDART00000122527; ENSDART:ENSDART00000076419
mRNA NCBI:NM_001002720
GeneDescription The lamin B receptor (LBR) is an integral membrane protein of the inner nuclear membrane that interacts with B-type lamins, chromatin and DNA.
GeneFunction Schild-Prüfert et al. (2006) found the possibility of zLBR involvement in cholesterol metabolism or that it acts as a sensor or receptor for sterol molecules. Schild-Prüfert et al. (2006) suggested that nucleoplasmic domain of the LBR might be involved in transcription regulation because this LBR domain was known to interact with the heterochromatin protein HP1and formed a tight complex with HP1 and histones H3/H4.
GeneCloning Schild-Prüfert et al. (2006) cloned the lbr gene.
GeneStructure This gene codes for three transcripts. ENSDART00000019145 has a transcriptional length of 3082 bps and contains 14 exons. The product ENSDARP00000015055 is 619 residue long. ENSDART00000122527 has a transcriptional length of 2961 bps and contains 13 exons. The product ENSDARP00000104747 is 619 residues long. ENSDART00000076419 has a transcriptional length of 2412 bps and 19 exons. The protein product ENSDARP00000070893 is 612 residues long.
Protein ENSDARP00000015055 ENSDARP00000104747 ENSDARP00000070893
ProteinDomainandFamilies has domain InterPro:IPR001171;
Motifs has motif Prosite:PS01017; Prosite:PS01018; PFAM:PF01222; PFAM:PF06966;
Expression ArrayExpress:ENSDARG00000014013;
GeneOntology GO:0016020; GO:0005637; GO:0042074; GO:0004872;
Orthologs Entrez:3930;
VariationAndRepeats RSID:rs40804825; RSID:rs40804825; RSID:rs40804825; RSID:rs40759085; RSID:rs40759085; RSID:rs40759085; RSID:rs40630958; RSID:rs40630958; RSID:rs40630958; RSID:rs41004813; RSID:rs41004813; RSID:rs41004813; RSID:rs41018727; RSID:rs41018727; RSID:rs41018727; RSID:rs41038285; RSID:rs41038285; RSID:rs41038285; RSID:rs40813450; RSID:rs40813450; RSID:rs40813450; RSID:rs40752056; RSID:rs40752056; RSID:rs40752056; RSID:rs41187276; RSID:rs41187276; RSID:rs41187276; RSID:rs40737969; RSID:rs40737969; RSID:rs40737969; RSID:rs40695810; RSID:rs40695810; RSID:rs40695810; RSID:rs41088187; RSID:rs41088187; RSID:rs41088187; RSID:rs41209781; RSID:rs41209781; RSID:rs41209781; RSID:rs41136591; RSID:rs41136591; RSID:rs41136591; RSID:rs40788104; RSID:rs40788104; RSID:rs40788104; RSID:rs40990768; RSID:rs40990768; RSID:rs40990768
DisordersAndMutations Schild-Prüfert et al. (2006) found that knockdown of zLBR by microinjection of 0.5-1.0 mM morpholino antisense oligonucleotides (MO) into 1- to 2-cell stage embryos reduced the amount of endogenous zLBR protein to approximately 10-20%. They further showed that the viability of MO-injected embryos within 24 h was reduced to 70-77%. They noticed that surviving 1-day-old embryos exhibited morphological alterations including reduced growth of head structures, retardation of tail growth and a bent backbone and tail.
RelatedPubMedArticles Schild-Prüfert, K.; Giegerich, M.; Schäfer, M.; Winkler, C.; Krohne, G.: Structural and functional characterization of the zebrafish lamin B receptor. Eur J Cell Biol. 85(8):813-24, Aug 2006. PMID:16759737 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-20 - SrishtiNanda
 
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