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kinase insert domain receptor like


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GeneName kdrl
Aliases ENSDARG:ENSDARG00000015815; flk, flk1, fetal liver kinase, vegr2, fk52c05, VEGFR-2, kdr, flk-1, wu:fk52c05, vegfr2, kdra, vegfr4,kinase insert domain receptor like
Description kinase insert domain receptor like
GenomicLocation Chromosome 14: 37,408,454-37,476,137 reverse strand
ExternalIDs Entrez:796537; EMBL:BC129158; UniGene:75094; ZFIN:ZDB-GENE-000705-1;
TranscriptID ENSDART:ENSDART00000007819
mRNA NCBI:NM_131472
GeneDescription This protein has a kinase activity, plays very important role in angiogenesis.
GeneFunction Habeck et al. (2002) demonstrated that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos. However, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis.Covassin et al. (2005) suggested that formation of arteries and veins in the embryo is governed in part by different Vegf receptor combinations, including flk1 and suggested a genetic mechanism for generating blood vessel diversity during vertebrate development.Bahary et al. (2007) isolated a duplicated zebrafish VegfA locus, termed VegfAb, and a duplicate RTK locus with homology to KDR/FLK1 (named Kdrb). They have also showed that Both VegfAa and VegfAb can individually bind and promote phosphorylation of both Flk1 (Kdra) and Kdrb proteins in vitro.
GeneCloning kdrl is contained in BAC : CH211-231B5, CH211-276G21, DKEY-183E23; EST: cssl:d0146, fk52c05; cDNA: MGC:158203.
GeneStructure This gene encodes one transcript. Transcript 1 (ENSDART00000007819) consists of 30 exons and is 5,389 bps in length. The protein product (ENSDARP00000007209) consists of 1,301 residues.
Protein ENSDARP00000007209
ProteinDomainandFamilies has domain InterPro:IPR007110; InterPro:IPR001824; InterPro:IPR013098; InterPro:IPR017441; InterPro:IPR000719; InterPro:IPR003598; InterPro:IPR013151; InterPro:IPR008266; InterPro:IPR003599; InterPro:IPR009134; InterPro:IPR001245; InterPro:IPR013783;
Motifs has motif Prosite:PS00107; Prosite:PS00109; Prosite:PS00240; Prosite:PS50011; Prosite:PS50835; PFAM:PF00047; PFAM:PF07679; PFAM:PF07714;
Expression ArrayExpress:ENSDARG00000015815;
GeneOntology GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0004872; GO:0016740; GO:0004714; GO:0005021; GO:0001525; GO:0030154; GO:0007275; GO:0006468; GO:0007169; GO:0048010; GO:0001525; GO:0001568; GO:0048844; GO:0035050; GO:0030878; GO:0016021; GO:0005887; GO:0016020;

VariationAndRepeats RSID:rs41140858; RSID:rs41210398; RSID:rs40987945; RSID:rs40981225; RSID:rs40827569; RSID:rs41209517; RSID:rs40834704; RSID:rs41220989; RSID:rs40598251; RSID:rs40609461; RSID:rs40628591; RSID:rs40605708; RSID:rs40715073; RSID:rs40969956; RSID:rs40645754; RSID:rs40603016; RSID:rs41114253; RSID:rs40619234; RSID:rs40599056; RSID:rs40625411; RSID:rs40609487; RSID:rs40594472; RSID:rs40598395; RSID:rs40622344; RSID:rs40612974; RSID:rs40605538; RSID:rs40626484; RSID:rs41195106; RSID:rs41224481; RSID:rs41247705; RSID:rs40909884; RSID:rs40603611; RSID:rs40836182; RSID:rs41052113; RSID:rs40797948
DisordersAndMutations ZFINID:ZDB-GENO-110511-4;ZFINID:ZDB-GENO-030804-1;ZFINID:ZDB-GENO-030804-1;ZFINID:ZDB-GENO-090605-1;ZFINID:ZDB-GENO-090605-2;ZFINID:ZDB-GENO-090603-5;ZFINID:ZDB-GENO-100709-1;ZFINID:ZDB-GENO-090603-6;ZFINID:ZDB-GENO-090610-6;ZFINID:ZDB-GENO-090603-18;ZFINID:ZDB-GENO-100610-4;ZFINID:ZDB-GENO-040827-1;ZFINID:ZDB-GENO-090603-19;
RelatedPubMedArticles Habeck H.; Odenthal J.; Walderich B.; Maischein H.; Schulte-Merker S; Tübingen: 2000 screen consortium. Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr Biol. 2002. 12(16):1405-12. PMID:12194822

Covassin L. D.; Villefranc J. A.; Kacergis M. C.; Weinstein B. M.; Lawson N. D.: Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc Natl Acad Sci U S A. 2006 103(17):6554-9. PMID:16617120

Bahary N.; Goishi K.; Stuckenholz C.; Weber G.; Leblanc J.; Schafer C. A.; Berman S. S.; Klagsbrun M.; Zon L. I.: Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood. 2007. 110(10):3627-36. PMID:17698971

Meng X.; Noyes M. B.; Zhu L. J.; Lawson N. D.; Wolfe S. A.: Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol. 2008 26(6):695-701. PMID:18500337

NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-06-24 - KritiKaushik
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