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jag1a

jagged 1a

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GeneInformationForm
GeneName jag1a
Aliases ENSDARG:ENSDARG00000030289; jag1; cb243; sb:cb243; serrateC; jag1a
Description jagged 1a
GenomicLocation chromosome 1 51614688-51667364 reverse strand
ExternalIDs Entrez:140421; EMBL:AY221107; UniGene:83677; ZFIN:ZDB-GENE-011128-2;
TranscriptID ENSDART:ENSDART00000137172; ENSDART:ENSDART00000047851; ENSDART:ENSDART00000123632
mRNA NCBI:NM_131861
GeneDescription Zebrafish jag1a is an important component of the Notch-signaling pathway. There are three known members of the zebrafish jagged family of notch-ligands namely, jag1a, jag1b and jag2.
GeneFunction Zecchin et al (2005) analyzed the sequence and embryonic expression pattern of zebrafish jagged1a, jagged1b, and jagged2. These genes, whose transcripts were detected by in situ hybridization from early somitogenesis, widely and dynamically expressed in embryos. The similarities of the expression patterns of jagged and delta genes in zebrafish suggested that the Jagged and Delta ligands were functionally redundant or required in specific combinations in many differentiation processes.
GeneCloning jag1a is contained in a BAC clone DKEY-210M15.
GeneStructure This gene encodes for a three transcripts. ENSDART00000137172 has 26 exons and a transcript length of 6,678 bps. The protein product (ENSDARP00000121170)consists of 1,253 amino acid residues. Transcript 2 (ENSDART00000047851) consists of 27 exons and has a transcript length of 6,643 bps and encodes for a 1,242 residues long protein product (ENSDARP00000047850). The third transcript (ENSDART00000123632), which consists of 28 exons, has a transcipt length of 6,084 bps and has a translatonal length of 1,242 residues (ENSDARP00000111427).
Protein ENSDARP00000121170 ENSDARP00000047850 ENSDARP00000111427
ProteinDomainandFamilies has domain InterPro:IPR001007; InterPro:IPR011651; InterPro:IPR001881; InterPro:IPR000152; InterPro:IPR006209; InterPro:IPR001438; InterPro:IPR013032; InterPro:IPR000742; InterPro:IPR001774; InterPro:IPR006210;
Motifs has motif Prosite:PS00010; Prosite:PS00022; Prosite:PS01186; Prosite:PS01187; Prosite:PS50026; Prosite:PS51051; PFAM:PF00008; PFAM:PF01414; PFAM:PF07645; PFAM:PF07974; PRINTS:PR00010; PRINTS:PR00011;
Expression ArrayExpress:ENSDARG00000030289
GeneOntology GO:0016020; GO:0016021; GO:0005786; GO:0005579; GO:0007275; GO:0007219; GO:0007154; GO:0006816; GO:0009968; GO:0005509; GO:0005262; GO:0019855;
Orthologs Entrez:182;
VariationAndRepeats RSID:rs40716506; RSID:rs40716506; RSID:rs40716506; RSID:rs40692170; RSID:rs40692170; RSID:rs40692170; RSID:rs41162069; RSID:rs41162069; RSID:rs41162069; RSID:rs41064324; RSID:rs41064324; RSID:rs41064324 ss252314139 ss252314139 ss252314139; RSID:rs40682348; RSID:rs40682348; RSID:rs40682348 ss252314135 ss252314135 ss252314135 ss252314132 ss252314132 ss252314132; RSID:rs40831654; RSID:rs40831654; RSID:rs40831654; RSID:rs40632578; RSID:rs40632578; RSID:rs40632578
DisordersAndMutations

RelatedPubMedArticles Zecchin, E.; Conigliaro, A.; Tiso, N.; Argenton, F.; Bortolussi M.: Expression analysis of jagged genes in zebrafish embryos. Dev Dyn. 233: 638-645, 2005. PMID:15830385 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - SrishtiNanda
 
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