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5-hydroxytryptamine (serotonin) receptor 1A a

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GeneName Htr1a
Aliases ENSDARG:ENSDARG00000093745; htr1aa
Description 5-hydroxytryptamine (serotonin) receptor 1A a
GenomicLocation chromosome 8 32789692-32791477 forward strand
ExternalIDs ZFIN:ZDB-GENE-071203-1; UniGene:92449; Entrez:100001828
TranscriptID ENSDART:ENSDART00000138217
mRNA NCBI:XM_001923087
GeneDescription Htr1aa is a 5-hydroxytryptamine receptor that is expressed in the raphe nuclei, retina, medulla oblongata, paraventricular organ, pretectal diencephalic complex and caudal zone of the periventricular hypothalamus, in line with the expression profiles of homologues.
GeneFunction Airhart et al. (2007) examined the effect of selective serotonin reuptake inhibitor (SSRI), fluoxetine (PROZAC), on the ontogeny of spontaneous swimming activity (SSA) in developing zebrafish. They detected the potential changes in SERT and HT1A receptor transcripts in 6 dpf larvae after a 24 h exposure to 4.6 μM fluoxetine on 5 dpf. Three regions of CNS were inidividually analysed, two defined brain regions, and spinal cord. The brain regions showed no effect on transcript levels after exposure to fluoxetine, but spinal cord showed decrease in both transcripts.Norton et al. (2008) compared the expression of 5-HT transporter genes slc6a4a and slc6a4b, and three 5-HT receptors, htr1aa, htr1ab, and htr1bd. From the analysis of serotonin transporter (SERT)- encoding genes they identified parallel genetic pathways that are used to build the 5-hydroxytryptamine system in Zebrafish. The receptors showed their expression in both the larval and adult brain. By comparing the expression of transporter and receptor genes they mapped the sites of autoreceptor activity within the brain.
GeneCloning Htr1a is contained in the BAC clone named DKEY-250L23 (library: Daniokey; Vector: pIndigoBAC-536).
GeneStructure The gene encodes for a single transcript ENSDART00000138217 which consists of a single exon and is 1,786 bps in length. The protein product (ENSDARP00000121666) consists of 398 residues.
Protein ENSDARP00000121666
ProteinDomainandFamilies has domain InterPro:IPR000276; InterPro:IPR017452; InterPro:IPR000610; InterPro:IPR000005; InterPro:IPR002231
Motifs has motif Prosite:PS00237; Prosite:PS50262; PFAM:PF00001
Expression ArrayExpress:ENSDARG00000093745
GeneOntology GO:0004930; GO:0004993; GO:0004871; GO:0007186; GO:0008283; GO:0050795; GO:0046883 GO:0007165; GO:0042310; GO:0016021; GO:0005887; GO:0016020; GO:0005886
Orthologs Entrez:3350;
VariationAndRepeats RSID:rs40621713; RSID:rs180146258; RSID:rs180146259; RSID:rs40796142; RSID:rs41214384; RSID:rs180146260

RelatedPubMedArticles Airhart, M. J.; Lee, D. H.; Wilson, T. D.; Miller, B. E.; Miller, M. N.; Skalko, R. G.: Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Neurotoxicol Teratol. 2007 Nov-Dec;29(6):652-64. Epub 2007 Jul 19. PMID:17761399 Norton, W. H.; Folchert, A.; Bally-Cuif, L.: Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain. J Comp Neurol. 2008 Dec 1;511(4):521-42. PMID:18839395 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - AnkitSabharwal
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