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hypermethylated in cancer 1

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GeneName hic1
Aliases ENSDARG:ENSDARG00000055493; HRG22; zgc:109776; hic2
Description hypermethylated in cancer 1
GenomicLocation chromosome 15 25015851-25025074 forward strand
ExternalIDs Entrez:100004301; EMBL:AJ429491; UniGene:83225; ZFIN:ZDB-GENE-040713-2;
TranscriptID ENSDART:ENSDART00000077853; ENSDART:ENSDART00000148190
mRNA NCBI:NM_001002314
GeneDescription Associated with bgrowth regulkation and plays a role in tumor suppression.
GeneFunction Bertrand et al. (2004) identified and studied the developmental expression of hic1 gene in zebrafish.It was found that hic1 was expressed during gastrulation until 24 hpf in a non regionalized manner.At 36 hpf the expression was predominant in mesenchyme of head around the nose and eyes, in the branchial arches and pectoral fin bud mesenchyme.a lower staining is also observed in hypochord as well pronephric duct. The expression pattern follows the same pattern till later stages except that there was aloss of expression in hypochord by 48 hpf.At 4.5 dpf the expression pattern is same but with alower intensity.
GeneCloning The gene is contained in BAC clone CH211-212M6 (Vector: pTARBAC2.1).
GeneStructure This gene encodes two transcripts. (ENSDART00000077853) which consists of 2 exons and is 2517 bps in length.The protein product (ENSDARP00000072319) consists of 737 residues(ENSDART00000148190) which consists of 2 exons and is 632 bps in length. The protein product (ENSDARP00000116361) consists of 195 residues.
Protein ENSDARP00000072319 ENSDARP00000116361
ProteinDomainandFamilies has domain InterPro:IPR007087; InterPro:IPR013087; InterPro:IPR000210; InterPro:IPR013069; InterPro:IPR011333; InterPro:IPR015880;
Motifs has motif Prosite:PS00028; Prosite:PS50097; Prosite:PS50157; PFAM:PF00096; PFAM:PF00651; PFAM:PF02214; PRINTS:PR00048;
Expression ArrayExpress:ENSDARG00000055493;
GeneOntology GO:0005622; GO:0006355; GO:0006353; GO:0006829; GO:0006350; GO:0031564; GO:0003676; GO:0008270; GO:0005515; GO:0046872; GO:0003677;
Orthologs Entrez:3090;
VariationAndRepeats RSID:rs179692515; RSID:rs179692667; RSID:rs179692393; RSID:rs179692672; RSID:rs179692679; RSID:rs179692450; RSID:rs179692434; RSID:rs179692425; RSID:rs179692531; RSID:rs179692498; RSID:rs179692355; RSID:rs179692335; RSID:rs179692547; RSID:rs179692563; RSID:rs179692627; RSID:rs179692334; RSID:rs179692406; RSID:rs179692394; RSID:rs179692507; RSID:rs179692475; RSID:rs179692560; RSID:rs179692474; RSID:rs179692392; RSID:rs179692613; RSID:rs179692339; RSID:rs179692435; RSID:rs179692391; RSID:rs179692446; RSID:rs179692460; RSID:rs179692521; RSID:rs179692336; RSID:rs179692329; RSID:rs179692400; RSID:rs179692383; RSID:rs179692491; RSID:rs179692610; RSID:rs179692541; RSID:rs179692378; RSID:rs179692687; RSID:rs179692436; RSID:rs179692608; RSID:rs179692669; RSID:rs179692481; RSID:rs179692516; RSID:rs179692603; RSID:rs179692539; RSID:rs179692590; RSID:rs179692390; RSID:rs179692546; RSID:rs179692513; RSID:rs179692370; RSID:rs179692451; RSID:rs179692579; RSID:rs179692691; RSID:rs179692648; RSID:rs179692398; RSID:rs179692438; RSID:rs179692490; RSID:rs179692582; RSID:rs179692638; RSID:rs179692524; RSID:rs179692477;

RelatedPubMedArticles Bertrand, S.; Pinte, S.; Stankovic-Valentin, N.; Deltour-Balerdi, S.; Guérardel, C.; Bégue, A.; Laudet, V.; Leprince, D.: Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene hic1.Biochim biophys acta. 16;1678(1):57-66, 2004. PMID:15093138 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-08-31 - AnkitSabharwal
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