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hatching enzyme 2

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GeneName he2
Aliases ENSDARG:ENSDARG00000022670; hypothetical protein LOC792176 h-2; hce2; wu:fb77c08; si:ch211-246m6.9; he2
Description hatching enzyme 2
GenomicLocation chromosome 22 14246501-14248780 forward strand
ExternalIDs Entrez:407075; EMBL:AB175620; UniGene:31549; ZFIN:ZDB-GENE-040518-1;
TranscriptID ENSDART:ENSDART00000032268; ENSDART:ENSDART00000146397; ENSDART:ENSDART00000137530
mRNA NCBI:NM_001098188
GeneDescription He2 is one of the hatching enzyme homolog in Zebrafish genome.
GeneFunction Inohaya et al. (1997) found that the hatching gland cells of Zebrafish originated from the anterior end of the hypoblast. Kawaguchi et al. (2006) analyzed the structures of hatching enzyme gene orthologs of vertebrates, using gene cloning and in silico cloning. Analysis of gene synteny and cluster structure between medaka and teradon, showed syntenic genes around the High choriolytic enzyme and low choriolytic enzyme genes and were found to be conserved between them, but such synteny was not found around the Zebrafish hatching enzyme genes. Thus they hypothesized Zebrafish hatching enzyme genes to be translocated from chromosome to chromosome and lost some of their introns during evolution.Sano et al. (2008) revealed ZHE2 to be rarely expressed in pre-hatching embryos using northern blot and RT-PCR analysis.
GeneCloning The gene is contained in BAC clone CH211-246M6 (Vector: pTARBAC2.1).
GeneStructure he2 gene codes for three transcripts. Transcript ENSDART00000032268 consists of 5 exons with the transcript length of 1885 bps. The protein product ENSDARP00000028799 consists of 271 residues. Transcript ENSDART00000146397 consists of 5 exons with the transcript length of 842 bps. The protein product ENSDARP00000118735 consists of 269 residues. Transcript ENSDART00000137530 consists of 3 exons with the transcript length of 794 bps. The protein product ENSDARP00000119185 consists of 96 residues.
Protein ENSDARP00000028799 ENSDARP00000118735 ENSDARP00000119185
ProteinDomainandFamilies has domain InterPro:IPR024079; InterPro:IPR001506; InterPro:IPR006026;
Motifs has motif Prosite:PS00142; PFAM:PF01400; PRINTS:PR00480;
Expression ArrayExpress:ENSDARG00000022670;
GeneOntology GO:0006508; GO:0008237; GO:0008533; GO:0008270;
Orthologs Entrez:431705
VariationAndRepeats RSID:rs180068725;

RelatedPubMedArticles Inohaya, K.; Yasumasu, S.; Araki, K.; Naruse, K.; Yamazaki, K.; Yasumasu, I.; Iuchi, I.; Yamagami, K.: Species-dependent migration of fish hatching gland cells that express astacin-like proteases in common [corrected]Dev Growth Differ. 1997 Apr;39(2):191-7. PMID:9108332 Kawaguchi, M.; Yasumasu, S.; Hiroi, J.; Naruse, K.; Suzuki, T.; Iuchi, I.: Analysis of the exon-intron structures of fish, amphibian, bird and mammalian hatching enzyme genes, with special reference to the intron loss evolution of hatching enzyme genes in Teleostei. Gene. 2007 May 1;392(1-2):77-88. Epub 2006 Nov 28. PMID:17222522 Sano, K.; Inohaya, K.; Kawaguchi, M.; Yoshizaki, N.; Iuchi, I.; Yasumasu, S.: Purification and characterization of zebrafish hatching enzyme - an evolutionary aspect of the mechanism of egg envelope digestion. FEBS J. 2008 Dec;275(23):5934-46. PMID:19021768 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r4 - 2013-08-31 - AnkitSabharwal
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