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h1m

linker histone h1m

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GeneInformationForm
GeneName h1m
Aliases ENSDARG:ENSDARG00000040344; linker histone H1M
Description linker histone h1m
GenomicLocation chromosome Zv9_NA660 14113-19625 reverse strand
ExternalIDs Entrez:327403; EMBL:BC083463; UniGene:75735; ZFIN:ZDB-GENE-030131-5614;
TranscriptID ENSDART:ENSDART00000059041
mRNA NCBI:NM_183071
GeneDescription H1m transcripts are present in all the blastomeres of early zebrafish embryos, uniformly distributed during blastula stages, but become restricted to the Primordial Germ cells during gastrulation and remain visible in PGCs as they migrate towards the region of the gonad.
GeneFunction Strasser et al. (2008) used h1m as one of the early Primordial germ cell (PGC) markers and analysed PGC expression in Tdrd7 knockdown embryos.Ferrante et al. (2008) observed the upregulation of h1m gene in ofd1-MO injected zebrafish embryos.
GeneCloning Wibrand et al. (2002) used subtractive cDNA cloning in zebrafish and reported linker H1m transcripts that mark the germ line from early gastrulation upto 18hrs of post fertilization.Müller et al. (2002) described the cloning, expression pattern and sub-cellular localization of the Zebrafish H1 type linker histone, H1M, which is expressed specifically in the PGCs, in the second phase of their development. Their analysis revealed h1m to be exclusively nuclear in both PGC and somatic cells of Zebrafish.
GeneStructure h1m encodes a single transcript ENSDART00000059041 which consists of 5 exons with the transcript length of 1,336 bps. The protein product ENSDARP00000059040 consists of 270 residues.
Protein ENSDARP00000059040
ProteinDomainandFamilies has domain InterPro:IPR005818; InterPro:IPR005819; InterPro:IPR011991;
Motifs has motif Prosite:PS51504; PFAM:PF00538; PRINTS:PR00624;
Expression ArrayExpress:ENSDARG00000040344;
GeneOntology GO:0005634; GO:0000786; GO:0006334; GO:0003677;
Orthologs

VariationAndRepeats

DisordersAndMutations

RelatedPubMedArticles Müller, K.; Thisse, C.; Thisse, B.; Raz, E.: Expression of a linker histone-like gene in the primordial germ cells in zebrafish. Mech Dev. 2002 Sep;117(1-2):253-7. PMID:12204266 Wibrand, K.; Olsen, L. C.: Linker histone H1M transcripts mark the developing germ line in zebrafish. Mech Dev. 2002 Sep;117(1-2):249-52. PMID:12204265 Ferrante, M. I.; Romio, L.; Castro, S.; Collins, J. E.; Goulding, D. A.; Stemple, D. L.; Woolf, A. S.; Wilson, S. W.: Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet. 2009 Jan 15;18(2):289-303. Epub 2008 Oct 29. PMID:18971206 Strasser, M. J.; Mackenzie, N. C.; Dumstrei, K.; Nakkrasae, L. I.; Stebler, J.; Raz, E.: Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development. BMC Dev Biol. 2008 May 28;8:58. PMID:18507824 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-13 - AnkitSabharwal
 
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