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G protein-coupled receptor kinase 7b

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GeneName grk7b
Aliases ENSDARG:ENSDARG00000055534; gprk7, grk7-2
Description G protein-coupled receptor kinase 7b
GenomicLocation chromosome 18 40140779-40154057 reverse strand
ExternalIDs Entrez:373871; EMBL:AY900005; UniGene:88577; ZFIN:ZDB-GENE-030904-3;
TranscriptID ENSDART:ENSDART00000077898
mRNA NCBI:NM_001033090
GeneDescription Grk7a is a member of the grk subfamily of proteins. It is one of the paralogs of GRK7 in zebrafish.. They are characterized by their ability to phosphorylate and desensitize agonist-occupied cell surface G protein-coupled receptor proteins .
GeneFunction Rinner et al. (2005) prepared riboprobes specific for grk7b, which showed that grk7b is expressed in the pineal gland and in low amounts in the photoreceptors. and was hardly detectable in the eyes. Wada et al. (2006) expressed Grk 7b in the brain devoid of the pineal gland . He performed in situ hybridization but can not detect grk7b showing its lower expression level in the eye. This shows Grk 7b functions as dominant subtype in zebrafish.
GeneCloning grk7b is contained in the BAC clone named DKEY-20H16(Library: Daniokey ; Vector: pIndigoBAC-536)
GeneStructure It encodes single transcripts (ENSDART00000077898) consists of 4 exons and is 1820 bps in length. The protein product (ENSDARP00000072364) consists of 548 residues.
Protein ENSDARP00000072364
ProteinDomainandFamilies has domain InterPro:IPR016137; InterPro:IPR011009; InterPro:IPR000342; InterPro:IPR002290; InterPro:IPR000239; InterPro:IPR017441; InterPro:IPR000961; InterPro:IPR000719; InterPro:IPR008271;
Motifs has motif Prosite:PS51285; Prosite:PS50132; Prosite:PS50011; Prosite:PS00107; Prosite:PS00108; PFAM:PF00069; PFAM:PF00615; PRINTS:PR00717;
Expression ArrayExpress:ENSDARG00000055534;
GeneOntology GO:0006468; GO:0007165; GO:0005524; GO:0004674; GO:0004871; GO:0004703; GO:0004672; GO:0000166; GO:0004872; GO:0016301; GO:0016740; GO:0050254;
Orthologs Entrez:131890;
VariationAndRepeats RSID:rs179730380; RSID:rs40856346; RSID:rs179730358; RSID:rs179730402; RSID:rs179730429; RSID:rs179730363; RSID:rs40827188; RSID:rs41115233; RSID:rs40697055; RSID:rs41099217

RelatedPubMedArticles Rinner, O.; Makhankov, Y.V,; Biehlmaier , O.; Neuhauss, S.C.: Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation. PMID:16039565 .Wada, Y.; Sugiyama, J.; Okano, T.; Fukada, Y..: GRK1 and GRK7: Unique cellular distribution and widely different activities of ops in phosphorylation in the zebrafish rods and cones. PMID:16787417 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r4 - 2013-08-22 - AnkitSabharwal
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