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follistatin-like 5

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GeneName fstl5
Aliases ENSDARG:ENSDARG00000040198; drMahya-1;fstl5
Description follistatin-like 5
GenomicLocation chromosome 14 49939833-50250520 reverse strand
ExternalIDs Entrez:566192; EMBL:AB231586; UniGene:133542; ZFIN:ZDB-GENE-070127-1;
TranscriptID ENSDART:ENSDART00000135479; ENSDART:ENSDART00000058796
mRNA NCBI:NM_001031842
GeneDescription Fstl5 is a novel member of the follistatin gene superfamily and consists of C- terminal domain. It is considered as a CNS related gene retained and evolved in specific bilaterian branches during evolution.
GeneFunction Tsuchimoto et al. (2005) reported fstl5 as a novel gene which encodes for novel secretory proteins. fstl5 expression was observed in dorsal telencephalon and ventral corpus cerebelli of brain and so, was concluded to be associated with learning and memory processing in brain.
GeneCloning fstl5 is contained in the BAC clone named CH211-89F22
GeneStructure This gene encodes 2 transcripts.Transcript (ENSDART00000058796) consists of 12 exons and is 2,145 bps in length .The protein product (ENSDARP00000058795) consists of 714 residues.Transcript (ENSDART00000105390) consists of 6 exons and is 663 bps in length .The protein product (ENSDARP00000096163) consists of 221 residues.
Protein ENSDARP00000118887 ENSDARP00000058795
ProteinDomainandFamilies has domain InterPro:IPR002350;InterPro:IPR018247; InterPro:IPR007110; InterPro:IPR013098; InterPro:IPR003598; InterPro:IPR011992; InterPro:IPR013783;
Motifs has motif Prosite:PS50222; Prosite:PS00018; Prosite:PS50835; PFAM:PF00036; PFAM:PF00050; PFAM:PF07679; PFAM:PF07648;
Expression ArrayExpress:ENSDARG00000040198;
GeneOntology GO:0005509;
Orthologs Entrez:56884;
VariationAndRepeats RSID:rs180110577; RSID:rs180110577; RSID:rs40895616; RSID:rs40895616; RSID:rs180110578; RSID:rs180110578; RSID:rs180110580; RSID:rs180110581; RSID:rs180110582; RSID:rs180110583; RSID:rs180110584; RSID:rs180110585; RSID:rs180110586; RSID:rs180110587; RSID:rs180110588; RSID:rs180110589; RSID:rs180110590; RSID:rs180110591; RSID:rs180110592; RSID:rs180110593; RSID:rs180110595; RSID:rs180110596; RSID:rs180110597; RSID:rs180110598; RSID:rs180110599; RSID:rs180110600; RSID:rs180110601; RSID:rs180110602; RSID:rs180110603; RSID:rs180110604; RSID:rs180110605; RSID:rs180110606; RSID:rs180110624; RSID:rs180110625; RSID:rs180110626; RSID:rs180110627; RSID:rs180110628; RSID:rs180110629; RSID:rs180110623; RSID:rs180110622; RSID:rs180110621; RSID:rs180110620; RSID:rs180110619; RSID:rs180110618; RSID:rs180110617; RSID:rs180110616; RSID:rs180110615; RSID:rs180110614; RSID:rs180110612; RSID:rs180110611; RSID:rs180110610; RSID:rs180110609; RSID:rs180110608; RSID:rs180110746; RSID:rs180110747; RSID:rs180110748; RSID:rs180110749; RSID:rs180110750; RSID:rs180110751; RSID:rs180110752; RSID:rs180110753
DisordersAndMutations ZFINID:ZDB-GENO-120411-137
RelatedPubMedArticles Tsuchimoto, M.; Yasuo, S.; Funada, M.; Aoki, M.; Sasagawa, H.; Yoshimura, T.; Tadauchi, O.; Cameron, S.A.; Kitagawa, Y.; Kadowaki, T.: Conservation of novel Mahya genes shows the existence of neural functions common between Hymenoptera and Deuterostome. Dev Genes Evol. ;215(11):564-74, 2005. PMID:16193321 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r3 - 2013-07-30 - AravindR
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