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fstl4

follistatin-like 4

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GeneInformationForm
GeneName fstl4
Aliases ENSDARG:ENSDARG00000044319;
Description follistatin-like 4
GenomicLocation chromosome 21 43393389-43576335 forward strand
ExternalIDs Entrez:571664; UniGene:94294; ZFIN:ZDB-GENE-070127-3;
TranscriptID ENSDART:ENSDART00000134365; ENSDART:ENSDART00000065083; ENSDART:ENSDART00000122944
mRNA NCBI:NM_001031843
GeneDescription Fstl4 is a novel member of the follistatin gene superfamily and consists of C- terminal domain. It is considered as a CNS related gene retained and evolved in specific bilaterian branches during evolution.
GeneFunction Tsuchimoto et al. (2005) carried out in situ hybridization in zebrafish brain section and found it to be associated with sensory information processing such as olfactory bulb and optic tectum. They found that it is expressed in visual and other sensory input (olfactory, auditory, mechano sensory) area. They also found fstl5 orthologs in honey bee, mouse, and human by using BLASTP and TBLASTN analysis.
GeneCloning [BAC] CH211-67D2
GeneStructure It encodes a single transcript (ENSDART00000065083) which consists of 9 exons and is 1,263 bps in length .The protein product (ENSDARP00000065082) consists of 421 residues.
Protein ENSDARP00000114256 ENSDARP00000065082 ENSDARP00000109943
ProteinDomainandFamilies has domain InterPro:IPR002048; InterPro:IPR002350; InterPro:IPR003598; InterPro:IPR007110;InterPro:IPR011992; InterPro:IPR013098; InterPro:IPR013783; InterPro:IPR018247;InterPro:IPR0182;
Motifs has motif Prosite:PS00018; Prosite:PS50222; Prosite:PS50835; PFAM:PF00036; PFAM:PF07648; PFAM:PF07679
Expression ArrayExpress:ENSDARG00000044319
GeneOntology GO:0005509
Orthologs Entrez:23105;
VariationAndRepeats RSID:rs40663694; RSID:rs40663695; RSID:rs40663702; RSID:rs40663703; RSID:rs180168743; RSID:rs41172947; RSID:rs40927781; RSID:rs40977617; RSID:rs180168742; RSID:rs41101488; RSID:rs41101488; RSID:rs41096384; RSID:rs41096384; RSID:rs40894233; RSID:rs40894233; RSID:rs40744609; RSID:rs40744609; RSID:rs41213555; RSID:rs41213555; RSID:rs40867933; RSID:rs40867933; RSID:rs40899759; RSID:rs40899759; RSID:rs40828101; RSID:rs40828101; RSID:rs41151638; RSID:rs41151638; RSID:rs180168741; RSID:rs180168741; RSID:rs41174114; RSID:rs41174114; RSID:rs41034107; RSID:rs41034107; RSID:rs40878476; RSID:rs40878476; RSID:rs40799921; RSID:rs40799921; RSID:rs40663696; RSID:rs40663696; RSID:rs40663697; RSID:rs40663697; RSID:rs180168740; RSID:rs180168740; RSID:rs180074623; RSID:rs180074623; RSID:rs40664198; RSID:rs40664198; RSID:rs180168739; RSID:rs180168739; RSID:rs40848622; RSID:rs40848622; RSID:rs41129322; RSID:rs41129322; RSID:rs40717570; RSID:rs40717570; RSID:rs40664202; RSID:rs40664202; RSID:rs41230841; RSID:rs41230841; RSID:rs40663232; RSID:rs40663232; RSID:rs40850182; RSID:rs40850182; RSID:rs41047819; RSID:rs41047819; RSID:rs40819035; RSID:rs40819035; RSID:rs41036046; RSID:rs41036046; RSID:rs40710887; RSID:rs40710887; RSID:rs40933245; RSID:rs40933245; RSID:rs41246690; RSID:rs41246690; RSID:rs41026187; RSID:rs41026187; RSID:rs41083080; RSID:rs41083080; RSID:rs40662727; RSID:rs40662727; RSID:rs40663698; RSID:rs40663698; RSID:rs40662732; RSID:rs40662732; RSID:rs40664199; RSID:rs40664199; RSID:rs40662728; RSID:rs40662728; RSID:rs40662730; RSID:rs40662730; RSID:rs40662731; RSID:rs40662731; RSID:rs40627242; RSID:rs40627242; RSID:rs41042734; RSID:rs41042734; RSID:rs41111545; RSID:rs41111545; RSID:rs40851030; RSID:rs40851030; RSID:rs41230926; RSID:rs41230926; RSID:rs180168738; RSID:rs180168738; RSID:rs180168737; RSID:rs180168737; RSID:rs41222413; RSID:rs41222413; RSID:rs41094833; RSID:rs41094833; RSID:rs41014396; RSID:rs41014396; RSID:rs40753197; RSID:rs40753197; RSID:rs41081328; RSID:rs41081328; RSID:rs41178869; RSID:rs41178869; RSID:rs40815259; RSID:rs40815259; RSID:rs40904859; RSID:rs40904859; RSID:rs40870018; RSID:rs40870018; RSID:rs180168736; RSID:rs180168736; RSID:rs41163624; RSID:rs41163624; RSID:rs40693022; RSID:rs40693022; RSID:rs180168735; RSID:rs180168735; RSID:rs40769261; RSID:rs40769261; RSID:rs40749389; RSID:rs40749389; RSID:rs40717303; RSID:rs40717303; RSID:rs180168734; RSID:rs180168734; RSID:rs180168733; RSID:rs180168733; RSID:rs180168732; RSID:rs180168732; RSID:rs180168731; RSID:rs180168731; RSID:rs40731511; RSID:rs40731511; RSID:rs41170865; RSID:rs41170865; RSID:rs41147688; RSID:rs41147688; RSID:rs40663226; RSID:rs40663226; RSID:rs40831371; RSID:rs40831371; RSID:rs40651418; RSID:rs40651418; RSID:rs180168730; RSID:rs180168730; RSID:rs40736599; RSID:rs40736599; RSID:rs41122230; RSID:rs41122230; RSID:rs40714072; RSID:rs40714072; RSID:rs40939615; RSID:rs40939615; RSID:rs40750780; RSID:rs40750780; RSID:rs40745899; RSID:rs40745899; RSID:rs40812180; RSID:rs40812180; RSID:rs40978432; RSID:rs40978432; RSID:rs41181491; RSID:rs41181491; RSID:rs40845493; RSID:rs40845493; RSID:rs40663701; RSID:rs40663701; RSID:rs180168729; RSID:rs180168729; RSID:rs40664200; RSID:rs40664200; RSID:rs40664203; RSID:rs40664203; RSID:rs180168728; RSID:rs180168728; RSID:rs40664194; RSID:rs40664194; RSID:rs40664195; RSID:rs40664195; RSID:rs40858507; RSID:rs40858507; RSID:rs41112201; RSID:rs41112201; RSID:rs180168727; RSID:rs180168727; RSID:rs40918231; RSID:rs40918231; RSID:rs40809804; RSID:rs40809804; RSID:rs41165410; RSID:rs41165410; RSID:rs41159471; RSID:rs41159471; RSID:rs180168726; RSID:rs180168726; RSID:rs40771876; RSID:rs40771876; RSID:rs40845484; RSID:rs40845484; RSID:rs40730928; RSID:rs40730928; RSID:rs180168725; RSID:rs180168725; RSID:rs180168724; RSID:rs180168724; RSID:rs40782321; RSID:rs40782321; RSID:rs41128303; RSID:rs41128303; RSID:rs41100201; RSID:rs41100201; RSID:rs40883653; RSID:rs40883653; RSID:rs40892324; RSID:rs40892324; RSID:rs40655074; RSID:rs40655074; RSID:rs40810174; RSID:rs40810174; RSID:rs41051014; RSID:rs41051014; RSID:rs40982184; RSID:rs40982184; RSID:rs41053512; RSID:rs41053512; RSID:rs41071264; RSID:rs41071264; RSID:rs41057488; RSID:rs41057488; RSID:rs40995566; RSID:rs40995566; RSID:rs41182407; RSID:rs41182407; RSID:rs40664197; RSID:rs40664197; RSID:rs180168723; RSID:rs180168723; RSID:rs41017064; RSID:rs41017064; RSID:rs40937684; RSID:rs40937684; RSID:rs41226977; RSID:rs41226977; RSID:rs180168722; RSID:rs180168722; RSID:rs40663233; RSID:rs40663233; RSID:rs40663231; RSID:rs40663231; RSID:rs40664196; RSID:rs40664196; RSID:rs40663230; RSID:rs40663230; RSID:rs40663229; RSID:rs40663229; RSID:rs40828573; RSID:rs40828573; RSID:rs40709733; RSID:rs40709733; RSID:rs40781894; RSID:rs40781894; RSID:rs41006231; RSID:rs41006231; RSID:rs180168721; RSID:rs180168721; RSID:rs180168720; RSID:rs180168720; RSID:rs40996279; RSID:rs40996279; RSID:rs41062431; RSID:rs41062431; RSID:rs40912689; RSID:rs40912689; RSID:rs41142102; RSID:rs41142102; RSID:rs41123845; RSID:rs41123845; RSID:rs41019150; RSID:rs41019150; RSID:rs40663699; RSID:rs40663699; RSID:rs40663228; RSID:rs40663228; RSID:rs41106873; RSID:rs41106873; RSID:rs41252519; RSID:rs41252519; RSID:rs41163785; RSID:rs41163785; RSID:rs40865505; RSID:rs40865505; RSID:rs180168719; RSID:rs180168718; RSID:rs180168717; RSID:rs180168716; RSID:rs180168715; RSID:rs180176291; RSID:rs180176290
DisordersAndMutations

RelatedPubMedArticles Tsuchimoto, M.; Yasuo, S.; Funada, M.; Aoki, M.; Sasagawa, H.; Yoshimura, T.; Tadauchi, O.; Cameron, S.A.; Kitagawa, Y.; Kadowaki, T.: Conservation of novel Mahya genes shows the existence of neural functions common between Hymenoptera and Deuterostome. PMID:16193321NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - AravindR
 
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