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enolase 2

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GeneName eno2
Aliases ENSDARG:ENSDARG00000014287;eno3; zgc:92418; wu:fc09h05; eno2
Description enolase 2
GenomicLocation chromosome 19 5697139-5715883 forward strand
ExternalIDs Entrez:402874; EMBL:BC072713; UniGene:78412; ZFIN:ZDB-GENE-040704-27;
TranscriptID ENSDART:ENSDART00000141559; ENSDART:ENSDART00000037126
mRNA NCBI:NM_001003848
GeneDescription Enolase 2 (gamma, neuronal), also known as ENO2 and neuron-specific enolase. It makes a phosphopyruvate hydratase.
GeneFunction Bai et al. (2007) identified the expression of eno2 by RNA in situ hybridization. the eno2 antisense cRNA probes hybridized with the cells that showed neuronal morphology and hence eno2 expression was localized in the grey matter nuclei and laminae throughout the brain and spinal cord and here too the most prominent labeling was seen in the telencephalon, deep laminae of the optic tectum, cranial nerve motor nuclei, granule cell and Purkinje cell layers of the cerebellum and brainstem reticular formation
GeneCloning eno2 is cloned in Tg(eno2:EGFP), Tg(eno2:Hsa.MAPT), Tg(eno2:mRFP)
GeneStructure This gene encodes three transcripts: (ENSDART00000037126) consists of 11 exons and is 2,328 bps in length. The protein product (ENSDARP00000032456) consists of 434 residues.(ENSDART00000141559) consists of 7 exons and is 698 bps in length. The protein product (ENSDARP00000114386) consists of 97 residues. (ENSDART00000151681) consists of 4 exons and is 552 bps in length.
Protein ENSDARP00000114386 ENSDARP00000032456
ProteinDomainandFamilies has domain InterPro:IPR000941;
Motifs has motif Prosite:PS00164; PFAM:PF00113; PFAM:PF03952; PRINTS:PR00148;
Expression ArrayExpress:ENSDARG00000014287;
GeneOntology GO:0016829,GO:0000287. GO:0004634, GO:0006096, GO:0000015
Orthologs [Entrez:Gene:2026]]
VariationAndRepeats ID rs40751601 rs40829758 rs40927215 rs40900961

RelatedPubMedArticles Bai, Q.; Garver, J.A.; Hukriede, N.A.; Burton, E.A .:Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene..Nucleic Acids Res.;35(19):6501-16, 2007. PMID:17897967 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-23 - ElvinLeonard
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