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endothelin receptor type A

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GeneName ednra
Aliases ENSDARG:ENSDARG00000011876; ednr-a; wu:fb75g12; ednra
Description endothelin receptor type A
GenomicLocation chromosome 1 36373658-36410470 forward strand
ExternalIDs Entrez:114550; EMBL:EF581835; UniGene:74572; ZFIN:ZDB-GENE-010906-2;
TranscriptID ENSDART:ENSDART00000125013; ENSDART:ENSDART00000128557; ENSDART:ENSDART00000010632; ENSDART:ENSDART00000111996; ENSDART:ENSDART00000089841; ENSDART:ENSDART00000089837; [[ENSDART:ENSDART00000148959
mRNA NCBI:NM_001099445
GeneDescription It is a G-protein coupled receptor.
GeneFunction Nair S. et al. (2007) experimentally demonstrated that ednra1 and ednra2 are involved in ventral arch development and ednra1 is required for jaw joint development.Morpholinos were used to inhibit the splicing of mature transcripts.Injection of ednra1 MO resulted in a slight shortening of the lower jaw and also caused joint fusion in both the dorsal and the ventral arches. But the injection of ednra 2 alone did not cause any visible defects.When these two MOs were co-injected there was a dramatic loss in lower jaw accompanied by loss of the two ventral arch cartilages i.e. ventral Meckelís and ventral ceratohyal.Thus these results showed that ednra1 is required for a subset of neural crest cells that form joints and ednra1 and ednra2 have roles in ventral arch development.

GeneStructure This gene encodes for a single transcript (ENSDART00000010632) which has 7 exons and is 1, 440 bps in length. The protein product (ENSARP000000273) consists of 359 residues.
Protein ENSDARP00000108726 ENSDARP00000002773 ENSDARP00000104346 ENSDARP00000084274 ENSDARP00000084270 ENSDARP00000124118
ProteinDomainandFamilies has domain InterPro:IPR000276; InterPro:IPR017452; InterPro:IPR002175; InterPro:IPR000499;
Motifs has motif Prosite:PS00237; PFAM:PF00001; PRINTS:PR00237; PRINTS:PR00366; PRINTS:PR00570; PRINTS:PR01421;
Expression ArrayExpress:ENSDARG00000011876
GeneOntology GO:0004930, GO:0048484, GO:0008217, GO:0042310, GO:0051216,GO:0016021; GO:0016020; GO:0005579; GO:0007186; GO:0007165; GO:0001584; GO:0004962; GO:0004872; GO:0004871;
Orthologs Entrez: Gene:1909


RelatedPubMedArticles Nair, S.; Li, W.; Cornell, R.; Schilling ,T.F.:Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish.Development.;134(2):335-45, 2007 . PMID:17166927 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-22 - ElvinLeonard
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