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cytochrome P450, family 19, subfamily A, polypeptide 1b

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GeneName cyp19a1b
Aliases ENSDARG:ENSDARG00000009852; AroB; cyp19; cyp19b; CYP19a2; P450aromB; zgc:92614
Description cytochrome P450, family 19, subfamily A, polypeptide 1b
GenomicLocation chromosome 25 4903097-4916762 reverse strand
ExternalIDs Entrez:60640; EMBL:AF226619; UniGene:10461; ZFIN:ZDB-GENE-001103-4;
TranscriptID ENSDART:ENSDART00000130307; ENSDART:ENSDART00000055885; ENSDART:ENSDART00000025590
mRNA NCBI:NM_131642
GeneDescription The cytochrome P450 Aromatase is the key enzyme catalyzing the conversion of androgens into estrogens. In zebrafish, the brain aromatase is encoded by cyp19b.
GeneFunction Goto R et al. (2004) showed that CYP19A2 was strongly expressed in the olfactory bulb (OB), ventral telencephalon (TEL), preoptic area (POA), and ventral/caudal hypothalamic zone (HT) of the brain, and in the anterior and posterior lobes of the pituitary. The regional distribution of the CYP19A2 mRNA did not vary with sex however transcript abundance varied within and between sexes . Differential expression of CYP19A1 and CYP19A2 in the brain, suggests that the two aromatase genes play different roles in the reproductive behavior and/or physiology of bony fish. Kallivretaki E et al. (2007) in an attempt to assess the role of cyp19a2 in the zebrafish brain during gonadal differentiation showed that cyp19a2 expression levels during zebrafish sexual differentiation cannot be assigned to a particular sex; the expression pattern in the brain is similar in both sexes and aromatase-positive cells appear to be mostly of radial glial nature.Lee Page Y et al. (2008) investigated the role of ERE flanking regions of cy19b in the control of cell-specific expression and showed that a 20 bp length motif, named G x RE (glial x responsive element), acts in synergy with the ERE to mediate the estrogenic induction specifically in glial cells. They also showed in vitro that this sequence binds factors exclusively present in glial or neuro-glial cells and is able to confer a glial specificity. This led to the understanding of cyp19b regulation by estrogens and allowed to identify a promoter sequence involved in the strong estrogen inducibility of cyp19b which is specific for glial cells.Hinfray n et al. (2006) investigated the effects of endocrine disrupting chemicals (EDCs) on aromatase function and showed that in ovary CYP19a mRNA level was predominant. They saw that estradiol (E2) led to a complete inhibition of both CYP19a expression and aromatase activities.
GeneCloning The gene is contained in a BAC clone CH211-286K11 (Vector: pTARBAC2.1).
GeneStructure This gene encodes for three transcripts, out of which one is novel;(ENSDART00000055885) consists of 10 exons, and is 1,203 bps in length. The protein product (ENSDARP00000055884) consists of 400 residues.(ENSDART00000025590) consists of 9 exons, and is 1,536 bps in length. The protein product (ENSDARP00000014320) consists of 511 residues.(ENSDART00000104814) consists of 10 exons, and is 1,209 bps in length. The protein product (ENSDARP00000095584) consists of 403 residues.(NOVEL)
Protein ENSDARP00000107907 ENSDARP00000055884 ENSDARP00000014320
ProteinDomainandFamilies has domain InterPro:IPR002401; InterPro:IPR001128;
Motifs has motif Prosite:PS00086; PFAM:PF00067; PRINTS:PR00359; PRINTS:PR00385; PRINTS:PR00463; PRINTS:PR00465;
Expression ArrayExpress:ENSDARG00000009852;
GeneOntology GO:0016020; GO:0005579; GO:0006118; GO:0043627; GO:0006826; GO:0006783; GO:0006879; GO:0048545; GO:0005506; GO:0020037; GO:0004497; GO:0016491; GO:0046872;
Orthologs Entrez:13075
VariationAndRepeats RSID:rs180038734; RSID:rs180038718; RSID:rs180038718; RSID:rs180038718; RSID:rs41113338; RSID:rs41113338; RSID:rs41113338; RSID:rs41027387; RSID:rs41027387; RSID:rs41027387; RSID:rs41180917; RSID:rs41180917; RSID:rs41180917; RSID:rs180038705; RSID:rs180038705; RSID:rs180038705; RSID:rs40711792; RSID:rs40711792; RSID:rs40711792; RSID:rs40816245; RSID:rs40816245; RSID:rs40816245; RSID:rs40703380; RSID:rs40703380; RSID:rs40703380; RSID:rs180038695; RSID:rs180038695; RSID:rs180038695; RSID:rs41142650; RSID:rs41142650; RSID:rs41142650; RSID:rs41178390; RSID:rs41178390; RSID:rs41178390; RSID:rs40755428; RSID:rs40755428; RSID:rs40755428; RSID:rs180038681; RSID:rs180038681; RSID:rs180038681

RelatedPubMedArticles Le Page, Y.; Menuet, A.; Kah, O.; Pakdel, F.: Characterization of a cis-acting element involved in cell-specific expression of the zebrafish brain aromatase gene. Mol Reprod Dev. ;75(10):1549-57,2008. PMID:18288647 . Kallivretaki, E.; Eggen, R.I.; Neuhauss, S.C.; Kah, O.; Segner, H.:The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiation. Dev Dyn. ;236(11):3155-66,2007. PMID:17937394 .Goto-Kazeto, R.; Kight, K.E.; Zohar, Y.; Place, A.R.; Trant, J.M.: Localization and expression of aromatase mRNA in adult zebrafish. Gen Comp Endocrinol. ;139(1):72-84,2004. PMID:15474538 .Le Page, Y.; Scholze, M.; Kah, O.; Pakdel, F.: Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system. Environ Health Perspect. ;114(5):752-8,2006. PMID:16675432 .Tong, S.K.; Chung, B.C.: Analysis of zebrafish cyp19 promoters. J Steroid Biochem Mol Biol. ;86(3-5):381-6. Review,2003. PMID:14623534 .Callard, G.V.; Tchoudakova, A.V.; Kishida, M.; Wood, E.: Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. J Steroid Biochem Mol Biol. ;79(1-5):305-14. Review, 2001. PMID:11850237 .Tong, S.K.; Chiang, E.F.; Hsiao, P.H.; Chung, B.: Phylogeny, expression and enzyme activity of zebrafish cyp19 (P450 aromatase) genes. J Steroid Biochem Mol Biol. ;79(1-5):299-303.2001. PMID:11850236 Chiang, E.F.; Yan, Y.L.; Guiguen, Y.; Postlethwait, J.; Chung, B.C.: Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol Biol Evol.;18(4):542-50, 2001. PMID:11264405 .Kishida, M.; Callard, G.V.: Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Endocrinology. ;142(2):740-50, 2001. PMID:11159846 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-27 - ParasSehgal
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