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cx35

connexin 35

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GeneInformationForm
GeneName cx35
Aliases ENSDARG:ENSDARG00000070781; cx35.1, gja9
Description connexin 35
GenomicLocation chromosome 20 10141634-10144544 reverse strand
ExternalIDs Entrez:378444; EMBL:AF462040; UniGene:27063; ZFIN:ZDB-GENE-030911-1;
TranscriptID ENSDART:ENSDART00000104234
mRNA NCBI:NM_194420
GeneDescription Connexins, or gap junction proteins, are a family of structurally-related transmembrane proteins that assemble to form vertebrate gap junctions. Each gap junction is composed of two hemichannels, or connexons, which are themselves each constructed out of six connexin molecules. Gap junctions are essential for many physiological processes, such as the coordinated depolarization of cardiac muscle, and proper embryonic development.
GeneFunction McLachlan et al.(2003) injected zebrafish cx35 RNA into paired xenopus oocyte to study the function of cx35.It was found that injection elicited intercellular electrical coupling with weak voltage senestivity.With the help of northern analysis and RT-PCR the cx 35 was first seen to be detectable 2 dpf and in adult the expression was found in brain and retina. They also studied the protein expression by sacrificing the zebrafish and collecting tissue sample from retina, whole eye (excluding lens), liver and brain. These tissues were homogenized and proteins were extracted and then ith the help of immunohistochemical techniques and western bloting a 35-36kDa band was recognized in zebrafish brain, retina and whole eye samples.
GeneCloning McLachlan et al. (2003) cloned Zebrafish Cx35 with a P1 Artificial Chromosome (PAC) library. Injection of the zebrafish Cx35 RNA into paired xenopus oocyte elicited intercellular electrical coupling with weak voltage sensitivity. It was seen that in an adult CX35 is expressed in brain and retina.
GeneStructure It codes for 1 transcript ENSDART00000104234 which has 2 exons with a transcript length of 915 bps The protein product (ENSDARP00000095009 ) consists of 304 residues
Protein ENSDARP00000095009
ProteinDomainandFamilies has domain InterPro:IPR013092; InterPro:IPR000500;
Motifs has motif Prosite:PS00407; Prosite:PS00408; PFAM:PF00029; PRINTS:PR00206;
Expression ArrayExpress:ENSDARG00000070781;
GeneOntology GO:0005922; GO:0016021; GO:0005921; GO:0007154; GO:0007267; GO:0005244; GO:0030054; GO:0005886; GO:0016020; GO:0016021
Orthologs Entrez:57369
VariationAndRepeats RSID:rs40684143; RSID:rs40811451; RSID:rs180076269; RSID:rs40705648; RSID:rs40865897; RSID:rs40766888; RSID:rs40966093; RSID:rs40806276; RSID:rs41019314; RSID:rs180105818; RSID:rs40955977; RSID:rs40652159; RSID:rs40812614; RSID:rs40822990; RSID:rs180076270; RSID:rs180076271
DisordersAndMutations

RelatedPubMedArticles McLachlan E, White TW, Ugonabo C, Olson C, Nagy JI, Valdimarsson G. Zebrafish Cx35: cloning and characterization of a gap junction gene highly expressed in the retina. J Neurosci Res. 15;73(6):753-64, 2003. PMID:12949901 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-27 - ParasSehgal
 
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