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crestin

crestin

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GeneInformationForm
GeneName crestin
Aliases ENSDARG:ENSDARG00000037083; crestin
Description crestin
GenomicLocation Chromosome 4: 64,256,000-64,257,781 forward strand. (Chr Start End Strand)
ExternalIDs Entrez:30186; EMBL:AF195881; UniGene:117160; ZFIN:ZDB-GENE-000208-13;
TranscriptID ENSDART:ENSDART00000079767
mRNA NCBI:XR_030084
GeneDescription Crestin is a member of family of retroelements, it is expressed in premigratory and migratory neural crest cells during somitogenesis.
GeneFunction Arduini et al. (2008) reported that crestin is expressed in the neural crest cells at the boundary of neural and non neural ectoderm during gastrulation.This expression continues over to the pigmentory and migratory neural crest cells and by 24 hpf crestin expression can be seen throughout the body.Olden et al. (2008) reported that crestin is expressed (which starts by 32 hpf) by enteric precursors when they migrate into the anterior intestine and this expression is continued in majority of enteric precursors between 34 hpf and 50 hpf , after this the crestin expression in the anterior region is stopped but is still continued in the posterior precurssors.It was concluded that the lack of crestin expression in anterior precursors suggest that anterior precursors are more differentiated as compared to posterior precursors.
GeneCloning

GeneStructure It codes for a single transcript (ENSDART00000079767) which has 1 exons and is 1,782 bps in length.The protein product (ENSDARP00000074219) consists of 593 residues
Protein ENSDARP00000074219
ProteinDomainandFamilies has domain
Motifs has motif
Expression ArrayExpress:ENSDARG00000037083;
GeneOntology GO:0005575; GO:0008150; GO:0003674;
Orthologs

VariationAndRepeats

DisordersAndMutations

RelatedPubMedArticles Arduini, B.L.; Gallagher, G.R.; Henion, P.D.: Zebrafish endzone regulates neural crest-derived chromatophore differentiation and morphology.PLoS ONE.;3(7):e2845, 2008 PMID:18665240 Olden, T.; Akhtar, T.; Beckman, S.A.; Wallace, K.N.: Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle. Genesis.;46(9):484-98, 2008. PMID:18781646 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - ParasSehgal
 
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