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Cdk7

cyclin-dependent kinase 7

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GeneInformationForm
GeneName Cdk7
Aliases ENSDARG:ENSDARG00000051916; MGC85821; zgc:85821; cdk7
Description cyclin-dependent kinase 7
GenomicLocation chromosome 5 54818487-54828537 reverse strand
ExternalIDs Entrez:405897; UniGene:3533; ZFIN:ZDB-GENE-010320-2;
TranscriptID ENSDART:ENSDART00000051003; ENSDART:ENSDART00000073627
mRNA NCBI:NM_212961
GeneDescription CDK7 is both a CDK-activating kinase (CAK), which phosphorylates cell-cycle CDKs within the activation segment (T-loop), and a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of the largest subunit of Pol II
GeneFunction Kondo et al, (1997) did immunoblotting experiments using monoclonal antibodies against cdk7 and which revealed that cdk7 are almost constant during oogenesis . Also, cdk7 is present in already active form in oocytes.Liu et al (2007) did sequence analysis of cdk7 with 86 % identity to the respective human orthologs. With RT-PCR and Insitu analysis they came to know that cdk7 is maternally loaded. Their data also suggest that their transcript were detected throughout development
GeneCloning The gene is contained in BAC clone CH211-198E13 (Vector: pTARBAC2.1).
GeneStructure Cdk 7 encodes for two transcripts. First transcript (ENSDART00000051003) consist of 12 exons and is 1,311bps in length. the product ENSDARP00000051002 consist of 345 residues. Second transcript (ENSDART00000073627) consist of 10 exons and is 1,149 bps in length. The product ENSDARP00000068117 consist of 311 residues
Protein ENSDARP00000051002 ENSDARP00000068117
ProteinDomainandFamilies has domain InterPro:IPR002290; InterPro:IPR017442; InterPro:IPR000719; InterPro:IPR017441; InterPro:IPR008271;
Motifs has motif Prosite:PS00107; Prosite:PS00108; Prosite:PS50011; PFAM:PF00069
Expression ArrayExpress:ENSDARG00000051916;
GeneOntology

Orthologs

VariationAndRepeats RSID:rs40596538; RSID:rs40596538; RSID:rs40618598; RSID:rs40618598; RSID:rs40605911; RSID:rs40605911; RSID:rs40605611; RSID:rs40605611; RSID:rs40606692; RSID:rs40606692; RSID:rs40620136; RSID:rs40620136; RSID:rs40969200; RSID:rs40969200; RSID:rs40621220; RSID:rs40621220; RSID:rs180173323; RSID:rs180173323; RSID:rs40606031; RSID:rs40606031; RSID:rs40740297; RSID:rs40740297; RSID:rs41133227; RSID:rs41133227; RSID:rs40830634; RSID:rs40830634; RSID:rs40739378; RSID:rs40739378; RSID:rs180173322; RSID:rs180173322; RSID:rs40646403; RSID:rs40646403; RSID:rs41233121; RSID:rs41233121; RSID:rs40804706; RSID:rs40804706; RSID:rs40738478; RSID:rs40738478; RSID:rs41137005; RSID:rs41137005; RSID:rs41034323; RSID:rs41034323; RSID:rs40718925; RSID:rs40718925; RSID:rs40824437; RSID:rs40824437; RSID:rs41103730; RSID:rs41103730; RSID:rs40754196; RSID:rs40754196; RSID:rs180173321; RSID:rs180173321; RSID:rs40980966; RSID:rs40980966; RSID:rs40772898; RSID:rs40772898; RSID:rs41118533; RSID:rs41118533
DisordersAndMutations

RelatedPubMedArticles Kondo, T.; Yanagawa, T.; Yoshida, N.; Yamashita, M. Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. Dev Biol.190(1):142-52,1997. PMID:9331337 Liu, Q.Y.; Wu, Z.L.; Lv, W.J.; Yan, Y.C.; Li, Y.P. Developmental expression of cyclin H and Cdk7 in zebrafish: the essential role of cyclin H during early embryo development. Cell Res. Feb;17(2):163-73,2007. PMID:17287831 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - ParasSehgal
 
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