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Cas-Br-M (murine) ecotropic retroviral transforming sequence

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GeneName cbl
Aliases ENSDARG:ENSDARG00000009958; zgc:92560, wu:fd16a12, Cas-Br-M (murine) ecotropic retroviral transforming sequence
Description Cas-Br-M (murine) ecotropic retroviral transforming sequence
GenomicLocation chromosome 15 22561590-22621848 forward strand
ExternalIDs Entrez:492364; EMBL:BC085671; UniGene:78552; ZFIN:ZDB-GENE-041114-207;
TranscriptID ENSDART:ENSDART00000006085; ENSDART:ENSDART00000130728
mRNA NCBI:NM_001007330
GeneDescription cbl gene plays an important role in calcium ion binding and cell surface receptor linked signal transduction.
GeneFunction Strausberg et al. (2002) identified the cDNA clone containing cbl ORF sequence. Nowak M et al (2011) used in vivo fluorescence correlation spectroscopy and automated image analysis to assess the role of endocytic sorting dynamics on fibroblast growth factor 8 (Fgf8) morphogen gradient interpretation. By interfering with the function of the ubiquitin ligase Cbl, they found an expanded range of Fgf target gene expression and a delay of Fgf8 lysosomal transport. However, the extracellular Fgf8 morphogen gradient remained unchanged, indicating that the observed signalling changes are due to altered gradient interpretation. We propose that regulation of morphogen signalling activity through endocytic sorting allows fast feedback-induced changes in gradient interpretation during the establishment of complex patterns.
GeneCloning The gene is contained in a BAC clone DKEY-257C10 (Vector: pIndigoBAC-536).
GeneStructure This gene encode two transcript. Transcript ENSDART00000130728 consist of 17 exons and is 4532 bps in length. The protein product (ENSDARP00000108901) consist of 913 residues Transcript ENSDART00000006085 consist of 16 exons and is 4069 bps in length. The protein product (ENSDARP00000027963) consist of 913 residues
Protein ENSDARP00000027963 ENSDARP00000108901
ProteinDomainandFamilies has domain InterPro:IPR003153; InterPro:IPR000449; InterPro:IPR014741; InterPro:IPR017907; InterPro:IPR000980; InterPro:IPR014742; InterPro:IPR011992; InterPro:IPR001841; InterPro:IPR013083; InterPro:IPR015940;
Motifs has motif Prosite:PS00518; PFAM:PF00097; PFAM:PF00627; PFAM:PF02262; PFAM:PF02761; PFAM:PF02762; PRINTS:PR01217;
Expression ArrayExpress:ENSDARG00000009958
GeneOntology GO:0005634; GO:0007242; GO:0007166; GO:0006816; GO:0006829; GO:0005509; GO:0004871; GO:0005515; GO:0008270; GO:0046872; GO:0016874; GO:0005262; GO:0019855;
Orthologs Entrez:867;
VariationAndRepeats rs41182130;

RelatedPubMedArticles Strausberg, R, L,; Feingold, , A,; Grouse, L, H,; Derge, J, G,; Klausner, R, D,; Collins, F, S,; Wagner, L,; Shenmen, C, M,; Schuler, G, D,; Altschul, S, F,; Zeeberg, B,; Buetow, K, H,; Schaefer, C, F,; Bhat, N, K,; Hopkins, R, F,; Jordan, H,; Moore, T,; Max, S, I,; Wang, J,; Hsieh, F,; Diatchenko, L,; Marusina, K,; Farmer, A, A,; Rubin, G, M,; Hong, L,; Stapleton, M,; Soares, M, B,; Bonaldo, M, F,; Casavant, T, L,; Scheetz, T, E,; Brownstein, M, J,; Usdin,T, B,; Toshiyuki S,; Carninci, P,; Prange, C,; Raha, S, S,; Loquellano N, A,; Peters, G, J,; Abramson, R, D,; Mullahy, S, J,; Bosak S, A,; McEwan, P, J;, McKernan, K, J,; Malek, J, A,; Gunaratne, P, H,; Richards, S,; Worley, K, C,; Hale, S, Garcia, A, M,; Gay, L, J,; Hulyk, S, W,; Villalon, D, K,; Muzny, D, M,; Sodergren, E, J,; Lu, X,; Gibbs,R,A,; Fahey , J,; Helton, E,; Ketteman, M,; Madan, A,; RodriguesS,; Sanchez, A,; Whiting, M,; Madan, A,; Young, A, C,; Shevchenko, Y,; Bouffard, G, G,; Blakesley, R, W,; Touchman, J, W,; Green, D,; Dickson M, C,; Rodriguez, A, C,; Grimwood, J,; Schmutz, J,; Myers, R, M,; Butterfield, Y, S,; Krzywinski, M, I,; Skalska, U,; Smailus, D, E,; Schnerch, A,; Schein, J, E,; Jones, S, J,; Marra, M, A.: Mammalian Gene Collection Program Team. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. PMID:12477932 1: McGrail M, Hatler JM, Kuang X, Liao HK, Nannapaneni K, Watt KE, Uhl JD, Largaespada DA, Vollbrecht E, Scheetz TE, Dupuy AJ, Hostetter JM, Essner JJ. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PLoS One. 2011 Apr 21;6(4):e18826. PubMed PMID: 21533036; PubMed Central PMCID: PMC3080878. NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - ParasSehgal
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