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caspase 9, apoptosis-related cysteine protease

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GeneName casp9
Aliases ENSDARG:ENSDARG00000004325; im:7136887, zgc:101776
Description caspase 9, apoptosis-related cysteine protease
GenomicLocation chromosome 23 25261112-25272611 forward strand
ExternalIDs Entrez:492763; EMBL:BC085434; UniGene:78866; ZFIN:ZDB-GENE-030825-5;
TranscriptID ENSDART:ENSDART00000047020; ENSDART:ENSDART00000137574
mRNA NCBI:NM_001007404
GeneDescription Caspase 9 is a member of caspase family.It is been linked to the mitochondrial death pathway. It is activated during programmed cell death
GeneFunction Kratz et al. (2006) found caspase 9 associated with proapoptotic factors as he found it to be stimulated with the subsequent release of proapoptoyic factors from mitochondrion. Eimon et al. (2006) injected caspase 9 mRNA in zebrafish embryos which induced apoptosis. Inohara et al. ( 2000) searched expressed-sequence tags (EST) public databases for zebrafish homologs proteins using TBLAST and identified caspase 9 with significant homology to mammalian caspases containing recognizable caspase-recruitment domains (CARDs), as they are found in their mammalian counterparts also.
GeneCloning casp9 is contained in BAC clone named DKEY-7I1(Library: Daniokey; Vector: pIndigoBAC-536)
GeneStructure It encodes for two transcripts.(ENSDART00000047020)which consists of 10 exons and is 1,734 bps in length .The protein product (ENSDARP00000047019) consists of 436 residues.Transcript ENSDART00000137574 consists of 2 exons and is 658 bps in length. No protein product.
Protein ENSDARP00000047019
ProteinDomainandFamilies has domain InterPro:IPR001309; InterPro:IPR002398; InterPro:IPR015917; InterPro:IPR002138; InterPro:IPR011600; InterPro:IPR017350; InterPro:IPR001315; InterPro:IPR011029; InterPro:IPR016129;
Motifs has motif Prosite:PS01121; Prosite:PS01122; Prosite:PS50207; Prosite:PS50208; Prosite:PS50209; PFAM:PF00619; PFAM:PF00656; PRINTS:PR00376;
Expression ArrayExpress:ENSDARG00000004325;
GeneOntology GO:0043065; GO:0005622; GO:0004197
Orthologs Entrez:842;
VariationAndRepeats RSID:rs180023801; RSID:rs180023858; RSID:rs180023647; RSID:rs180023778; RSID:rs41202513; RSID:rs40792088; RSID:rs180023669; RSID:rs180023739; RSID:rs180023864; RSID:rs180023888; RSID:rs180023805; RSID:rs180023552; RSID:rs180023733; RSID:rs180023548; RSID:rs180023543; RSID:rs180023772; RSID:rs180023837; RSID:rs180023837; RSID:rs180023812; RSID:rs180023812; RSID:rs180023611; RSID:rs180023611; RSID:rs180023474; RSID:rs180023474; RSID:rs180023760; RSID:rs180023760; RSID:rs180023579; RSID:rs180023579; RSID:rs180023560; RSID:rs180023560; RSID:rs180023804; RSID:rs180023804; RSID:rs180023622; RSID:rs180023622; RSID:rs180023642; RSID:rs180023642; RSID:rs180023889; RSID:rs180023889; RSID:rs180023617; RSID:rs180023617; RSID:rs180023562; RSID:rs180023562; RSID:rs180023550; RSID:rs180023550; RSID:rs180023890; RSID:rs180023890; RSID:rs180023661; RSID:rs180023661; RSID:rs180023509; RSID:rs180023509; RSID:rs180023745; RSID:rs180023745; RSID:rs180023538; RSID:rs180023538
DisordersAndMutations Morpholino MO1-casp9(5' - GATGGAAAAACACACTTACGGACTG - 3') has been directed against caspase 9. Apoptosis was observed in the spinal cord.
RelatedPubMedArticles Inohara,N.;Nunez, G.: Genes with homology to mammalian apoptosis regulators identified in Zebrafish.Cell Death Differ. ;7(5):509-10, 2000. PMID:10917738 .Kratz, E.; Eimon, P.M.; Mukhyala, K.; Stern, H.; Zha, J.; Strasser, A.; Hart, R.; Ashkenazi A.: Functional characterization of the Bcl-2 gene family in the zebrafish .Cell Death Differ.;13(10):1631-40, 2006. PMID:16888646 Eimon, P.M.; Kratz, E., Varfolomeev, E., Hymowitz, S.G., Stern, H., Zha, J., and Ashkenazi, A. Delineation of the cell-extrinsic apoptosis pathway in the Zebrafish.Cell Death Differ.;13(10):1619-30, 2006. PMID:16888647 . NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - ParasSehgal
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