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casp7

caspase 7, apoptosis-related cysteine peptidase

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GeneInformationForm
GeneName casp7
Aliases ENSDARG:ENSDARG00000091836; zgc:110595, caspase-7a
Description caspase 7, apoptosis-related cysteine peptidase
GenomicLocation chromosome 12 32233742-32247789 reverse strand
ExternalIDs Entrez:553634; EMBL:BC095327; UniGene:88746; ZFIN:ZDB-GENE-050522-506;
TranscriptID ENSDART:ENSDART00000124035
mRNA NCBI:NM_001020607
GeneDescription Caspase 7 is a member of caspase family.They belongs to Class II caspases, with short N-terminal prodomains. .They targets cellular proteins for proteolytic cleavage. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.
GeneFunction Yabu et al. (2001) suggested caspase 7 as a member of caspase cascade, which induces an apoptotic pathway Kratz et al. ( 2006) investigated the role of caspase 7 in apoptosis as it is activated and cleaved when caspase 9 is activated.
GeneCloning Casp 7 is contained in BAC clone named CH211-28P3 (Library: CHORI-211; Vector: pTARBAC2.1)
GeneStructure It encodes a single transcript (ENSDART00000124035)which cconsists of 8 exons and is 2648 bps in length .The protein product (ENSDARP00000105932) consists of 316 residues.
Protein ENSDARP00000105932
ProteinDomainandFamilies has domain InterPro:IPR001309; InterPro:IPR011600; InterPro:IPR016129; InterPro:IPR002398; InterPro:IPR015917; InterPro:IPR002138; InterPro:IPR015471;
Motifs has motif Prosite:PS01121; Prosite:PS01122; PFAM:PF00656; PRINTS:PR00376;
Expression ArrayExpress:ENSDARG00000091836;
GeneOntology GO:0006915; GO:0005737; GO:0004197
Orthologs Entrez:840;
VariationAndRepeats RSID:rs179895236; RSID:rs179895227; RSID:rs179895280; RSID:rs179895151; RSID:rs179895268; RSID:rs179895278; RSID:rs179895224; RSID:rs179895243; RSID:rs179895242; RSID:rs179895214; RSID:rs179895234; RSID:rs179895193; RSID:rs179895211; RSID:rs179895170; RSID:rs179895196; RSID:rs179895261; RSID:rs179895187; RSID:rs179895260; RSID:rs179895188; RSID:rs179895163; RSID:rs179895231; RSID:rs179895246; RSID:rs179895223; RSID:rs179895271; RSID:rs179895197; RSID:rs179895219; RSID:rs179895253; RSID:rs179895147; RSID:rs179895178; RSID:rs179895229; RSID:rs179895250; RSID:rs179895152; RSID:rs179895216
DisordersAndMutations

RelatedPubMedArticles Yabu, T.; Kishi, S.; Okazaki, T.; Yamashita, M.: Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo. Biochem J. ;360(Pt 1):39-47, 2001. PMID:11695990 Kratz, E.; Eimon, P.M.; Mukhyala, K.; Stern, H.; Zha, J.; Strasser, A.; Hart, R.; Ashkenazi A.:Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ. ;13(10):1631-40.2006. PMID:16888646 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - ParasSehgal
 
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