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GeneName Bty
Aliases ENSDARG:ENSDARG00000040860; Bty
Description Bloodthirsty
GenomicLocation chromosome 15 17142483-17153328 reverse strand
ExternalIDs ZFIN:ZDB-GENE-020620-2; Entrez:246711; EMBL:AY454307; UniGene:148704;
TranscriptID ENSDART:ENSDART00000147590; ENSDART:ENSDART00000007454; ENSDART:ENSDART00000059894; ENSDART:ENSDART00000092911; ENSDART:ENSDART00000105111; ENSDART:ENSDART00000146200; ENSDART:ENSDART00000143186;
mRNA NCBI:NM_001020475
GeneDescription Bloodthirsty(bty) gene encodes 547-residue protein that contains sequential RING finger, B Box, coiled-coil, and B30.2 domains.
GeneFunction Yergeau et al. (2005) used antisense morpholino oligonucleotides (MOs) to knockdown bty expression in zebrafish embryos. This eliminated the production of erythrocytes of primitive lineage, and this morphant phenotype was rescued by co-injecting synthetic bty mRNA that contains an artificial 5-UTR. Bty knockdown reduced the abundance of several late-erythropoietic mRNAs, whereas expression of genes that mark early erythropoiesis, myelopoiesis, and vasculogenesis was unaffected by MO injection. These results suggest the requirement of bloodthirsty for terminal differentiation of erythroid progenitors of the primitive lineage.
GeneCloning Yergeau et al. (2005) cloned the orthologous zebrafish gene from a kidney cDNA library and analyzed its function.
GeneStructure The gene encodes for 7 transcripts.

The transcript ENSDART00000147590 consists of 7 exons and is 1890 bps in length. The protein protduct (ENSDARP00000114618) consists of 532 residues.
The transcript ENSDART00000007454 consists of 7 exons and is 1680 bps in length. The protein protduct (ENSDARP00000025807) consists of 559 residues.
The transcript ENSDART00000059894 consists of 6 exons and is 1793 bps in length. The protein product (ENSDARP00000059893) consists of 532 residues.
The transcript ENSDART00000092911ENSDART00000105112 consists of 8 exons and is 2061 bps in length. The protein product (ENSDARP00000087343) consists of 557 residues.
The transcript ENSDART00000105111 consists of 5 exons and is 1213 bps in length. The protein product (ENSDARP00000095882) consists of 326 residues.
The transcript ENSDART00000146200 consists of 6 exons and is 810 bps in length. No protein product.
The transcript ENSDART00000143186 consists of 6 exons and is 1999 bps in length. No protein product.

Protein ENSDARP00000114618 ENSDARP00000025807 ENSDARP00000059893 ENSDARP00000087343 ENSDARP00000095882
ProteinDomainandFamilies has domain InterPro:IPR000315; InterPro:IPR003877; InterPro:IPR013083; InterPro:IPR001870; InterPro:IPR006574; InterPro:IPR001841; InterPro:IPR017907; InterPro:IPR003879;
Motifs has motif Prosite:PS00518; Prosite:PS50089; Prosite:PS50119; Prosite:PS50188; PFAM:PF00622; PFAM:PF00643;
Expression ArrayExpress:ENSDARG00000040860


VariationAndRepeats rs40787221; rs40787221; rs40787221; rs3728952; rs3728952; rs3728952; rs3728953; rs3728953; rs3728953; rs40913982; rs40913982; rs40913982; rs40913982; rs40913982;
DisordersAndMutations Yergeau et al. (2005) addressed the function of bty by using fluorescein isothiocyanate(FITC)- tagged antisense MOs. Zebb302 was targeted to the start codon and 21 base pairs downstream (5V-CAGTGGATTACTGGAGGAGGACAT-3V), and its control, Zebb302b (5V-CAGTGAATCACTGGAAGAAGACAT-3V), covered the same target sequence but contained mismatches at four positions to prevent efficient binding. Zebb302a was targeted to the 5-UTR immediately upstream of the start codon (5-ATATGGAGGTAAACGGTC-3), and the control, Zebb302c (5-ATGTGCAGGTAATCGCTC-3),covered the same target sequence but with 4-bp mismatch.
RelatedPubMedArticles Yergeau, D. A.; Cornell, C. N.; Parker, S. K.; Zhou, Y.; Detrich, H. W.; bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in zebrafish. Dev Biol. 2005 Jul 1;283(1):97-112. PMID:15890331 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r7 - 2011-12-02 - RajivRana
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