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btg2

B-cell translocation gene 2

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GeneInformationForm
GeneName btg2
Aliases ENSDARG:ENSDARG00000020298; cb56; btg-b; fb17g09; wu:fb17g09; wu:fi03a06; btg2
Description B-cell translocation gene 2
GenomicLocation chromosome 22 754599-757142 reverse strand
ExternalIDs Entrez:30079; EMBL:BC044343; UniGene:76624; ZFIN:ZDB-GENE-000210-15;
TranscriptID ENSDART:ENSDART00000019155
mRNA NCBI:NM_130922
GeneDescription BTG/tob family proteins are thought to be a potential tumor suppressors due to their anti-proliferative activity. BTG2 is one of the p53 target genes, however, the p53 response elements showing the pentamer orientation in each decamer is variable.
GeneFunction Sakaguchi et al. (2001) used in situ hybridization analysis to show the ubiquitous expression of btg-b at the sphere stage. As the gastrulation proceeds, the expression becomes restricted to the shield region, and then it shifts to the prechordal plate. At the tailbud stage, the boundary of the neural and the non-neural ectoderms as well as a few clusters of cells in the future hindbrain region start to express btgb. At the segmentation stage, btg-b is mainly expressed in the polster, the forebrain, the hindbrain, the somites, and the presomitic mesoderm. They also did phylogenetic analysis and concluded btg-a and btg-b to be a member of BTG1/2-related subfamilyof the BTG/tob family.
GeneCloning

GeneStructure Btg2 encodes a single transcript ENSDARG00000020298 which consists of 2 exons and is 2,063 bps in length. The protein product ENSDARP00000006800 consists of 165 residues.
Protein ENSDARP00000006800
ProteinDomainandFamilies has domain InterPro:IPR002087;
Motifs has motif Prosite:PS00960; Prosite:PS01203; PFAM:PF07742; PRINTS:PR00310;
Expression ArrayExpress:ENSDARG00000020298;
GeneOntology

Orthologs Entrez:65980;
VariationAndRepeats RSID:rs180067420; RSID:rs40632670; RSID:rs40656612; RSID:rs40644959; RSID:rs40676022; RSID:rs40656078; RSID:rs40634739; RSID:rs40656079; RSID:rs40637673; RSID:rs40669154; RSID:rs40654896; RSID:rs40664717; RSID:rs40640953; RSID:rs40647506; RSID:rs40641763; RSID:rs41054249; RSID:rs41152409; RSID:rs40711315; RSID:rs41194955; RSID:rs180067419
DisordersAndMutations

RelatedPubMedArticles Sakaguchi, T,; Kuroiwa, A.; Takeda, H.: Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis. Mech Dev. 2001 Jun;104(1-2):113-5. PMID:11404086 Lim, I. K.: TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule. J Cancer Res Clin Oncol. 2006 Jul;132(7):417-26. Epub 2006 Feb 3. PMID:16456675 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-08-11 - DivyaJagga02
 
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