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basic helix-loop-helix family, member e22

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GeneName bhlhb5
Aliases ENSDARG:ENSDARG00000058039; bhlhb5; Beta3.1; MGC64225; zgc:64225; wu:fq25e11; bhlhe22
Description basic helix-loop-helix family, member e22
GenomicLocation chromosome 24 25069289-25071294 forward strand
ExternalIDs Entrez:393930; EMBL:BC053312; UniGene:84568; ZFIN:ZDB-GENE-040426-1411;
TranscriptID ENSDART:ENSDART00000080840
mRNA NCBI:NM_200955
GeneDescription Beta3.1 is more closely related to Beta3 factors of other vertebrates which is 98% identical to the bHLH domain.
GeneFunction Adolf et al. (2004) reported the isolation of atoh1.2 and beta3.1, the members of zebrafish neural bHLH genes. Both the genes are found to be expressed in the late embryonic and early larval anterior hindbrain.Atoch1.2 and beta3.1 are transcribed in distinct precursors. They detected the expression of beta3.1 at the tail-bud stage in two cell clusters of the anterior neural plate. At 3 somites, these two clusters can be localized to rhombomere1 by comparison with krox20, restricted at that stage to rhombomere3. Beta3.1 expression in these clusters merges at the midline at 7 somites and is switched off by 14 somites, by which stage prominent beta3.1 expression is found in the more posterior hindbrain and spinal cord.
GeneCloning The gene is contained in BAC clone CH211-277B21 (Vector: pTARBAC2.1).
GeneStructure Bhlhb5 encodes for a single transcript ENSDARG00000058039 which consists of a single exon and is 1,789 bps in length. The protein product ENSDARP00000075286 consists of 261 residues.
Protein ENSDARP00000075286
ProteinDomainandFamilies has domain InterPro:IPR011598
Motifs has motif Prosite:PS50888; PFAM:PF00010;
Expression ArrayExpress:ENSDARG00000058039;
GeneOntology GO:0005634; GO:0045449; GO:0030528;
Orthologs Entrez:23719 ; Entrez:59058
VariationAndRepeats ID rs41069673 rs41069673 rs41152782 rs41152782 rs180061412 rs180061412

RelatedPubMedArticles Adolf, B.; Bellipanni, G.; Huber, V.; Bally-Cuif, L.: atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrain. Gene Expr Patterns. 2004 Nov;5(1):35-41. PMID:15533816 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - DivyaJagga02
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