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basic helix-loop-helix domain containing, class B, 3 like

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GeneName bhlhb3l
Aliases ENSDARG:ENSDARG00000041691; dec2; si:ch211-154h20.6; bhlhb3l
Description basic helix-loop-helix domain containing, class B, 3 like
GenomicLocation chromosome 18 15785020-15789333 forward strand
ExternalIDs Entrez:563771; EMBL:BX000347; UniGene:85246; ZFIN:ZDB-GENE-050419-146;
TranscriptID ENSDART:ENSDART00000061106
mRNA NCBI:NM_001039107
GeneDescription Dec2 (also called as Bhlhb3 or sharp1) encodes for basic helix-loop-helix (bHLH) transcription factors related to rat Hes, Drosophila Hairy, and Enhancer of split suppressed Per transactivation by CLOCK/BMAL1 through competition for E-boxes and/ or protein–protein interaction with BMAL1.
GeneFunction Abe et al. (2006) identified and characterized zebrafish orthologs of mammalian Dec1 and Dec2 genes and analyzed their functions in directly light-sensitive circadian clock in zebrafish peripheral cells. The results demonstrated the involvement of Dec genes in the circadian clock as negative elements, making additional negative feedback loops. The phylogenetic analysis indicated close relationship of zDEC1and zDEC2 with that of mammalian DEC1 and DEC2, respectively.
GeneCloning Abe et al. (2006) obtained cDNA clones encoding entire protein coding sequences, by performing PCR using BRF41 cDNA as a template with zDec1-specific primers(5’- ATTCGAGGAAAACACATGTGG-3’ and 5’-TTCAACCGAACCCTCTTCG-3’ derived from BX914197) and zDec2-specific primers(5’-TTGGATTAACCAAACCTCACTG-3’ and5’-AGATTTTCATTCAAGGAATCAG-3’ derived from CR318631)
GeneStructure Bhlh3bl encodes a single transcript ENSDARG00000041691 which consists of 5 exons and is 3.155 bps in length. The protein product ENSDARP00000061105 consists of 421 residues.
Protein ENSDARP00000061105
ProteinDomainandFamilies has domain InterPro:IPR003650; InterPro:IPR011598;
Motifs has motif PFAM:PF00010; PFAM:PF07527; PRINTS:PR00308;
Expression ArrayExpress:ENSDARG00000041691;
GeneOntology GO:0005634; GO:0045449; GO:0006355; GO:0003677; GO:0030528; GO:0016564;
Orthologs Entrez:168620;
VariationAndRepeats RSID:rs180086235; RSID:rs180086236; RSID:rs40928859; RSID:rs40928859; RSID:rs40928859; RSID:rs180086237; RSID:rs180086238

RelatedPubMedArticles Abe, T.; Ishikawa, T.; Masuda, T.; Mizusawa, K.; Tsukamoto, T.; Mitani, H.; Yanagisawa, T.;Todo, T.; Iigo, M.: Molecular analysis of Dec1 and Dec2 in the peripheral circadian clock ofzebrafish photosensitive cells. Biochem Biophys Res Commun. 2006 Dec 29;351(4):1072-7. Epub 2006 Nov 7. PMID:17097613 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-26 - DivyaJagga02
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