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achaete-scute complex-like 1a (Drosophila)

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GeneName ascl1a
Aliases ENSDARG:ENSDARG00000038386; zasha, Zash-1a, zash1a, id:ibd5085, pia, asha, pituitary absent
Description achaete-scute complex-like 1a (Drosophila)
GenomicLocation chromosome 4 16485295-16487377 forward strand
ExternalIDs Entrez:30466; EMBL:U14587; UniGene:314; ZFIN:ZDB-GENE-980526-90;
TranscriptID ENSDART:ENSDART00000056005
mRNA NCBI:NM_131219.
GeneDescription Ascl1a gene encodes for basic helix-loop-helix transcription factor regulated by floating head gene (flh) in epiphysial neural progenitors.
GeneFunction Allende et al. (1994) used two achaete-scute homolog sequences, Zash-1a and Zash-1b, in the analysis of mutations affecting the development of central nervous system in Zebrafish embryos. They noticed that in the mutant Cyclops, Zash-1a transcripts are absent from the ventral region of the tegmentum and in the ventral cells of rhombomere 1, while more dorsal expression regions are unaffected. Cau et al. (2003) compared the epiphysical phenotypes of flh mutant and of ash1a/ngn1 double morphants and revealed that the reduced expression of ash1a and ngn1 can account for most of the neurogenesis defects in flh-mutant epiphysis. They demonstrated ash1a and ngn1 as essential regulators of neurogenesis that function downstream of flh and upstream of neuroD.Yurco et al. (2007) observed injury-induced enhanced expression of ash1a in Müller cells. They suggested a model of vertebrate retinal repair in which damage-induced expression of proneural genes, plus canonical Notch-Delta signaling could contribute to retinal stem cell promotion and subsequent regenerative neurogenesis.
GeneCloning The gene is contained in BAC clones CH211-260P3 (Vector: pTARBAC2.1) and DKEY-264K15 (Vector: pIndigoBAC-536).
GeneStructure This gene encodes for a single transcript, (ENSDART00000056005) which consists of 2 exons and 1,977 bps. The protein product (ENSDARP00000056004) consists of 196 residues.
Protein ENSDARP00000056004
ProteinDomainandFamilies has domain InterPro:IPR011598; InterPro:IPR015660; InterPro:IPR001092;
Motifs has motif Prosite:PS50888; PFAM:PF00010; PRINTS:PR00044;
Expression ArrayExpress:ENSDARG00000038386;
GeneOntology GO:0005634; GO:0045449; GO:0007399; GO:0021984; GO:0002070; GO:0006355; GO:0006353; GO:0031564; GO:0006350; GO:0030154; GO:0021575; GO:0030528; GO:0003677;
Orthologs Entrez:429;
VariationAndRepeats RSID:rs180036407; RSID:rs180036408; RSID:rs180036409
DisordersAndMutations ZFINID:ZDB-GENO-040716-9; ZFINID:ZDB-GENO-110816-2; ZFINID:ZDB-GENO-110816-2; ZFINID:ZDB-GENO-050209-28;
RelatedPubMedArticles Allende, M. L.; Weinberg, E. S.: The expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Dev Biol. 1994 Dec; 166(2):509-30. PMID:7813774 Cau, E.; Wilson, S. W.: Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis. Development. 2003 Jun; 130(11):2455-66. PMID:12702659 Yurco, P.; Cameron, D. A.: Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina. Vis Neurosci. 2007 May-Jun;24(3):437-43. PMID:17822581 NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - DivyaJagga
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