Tags:
create new tag
, view all tags

ahcy

S-adenosylhomocysteine hydrolase

Rate Information on this Page
Score: 0, My vote: 0, Total votes: 0

GeneInformationForm
GeneName ahcy
Aliases ENSDARG:ENSDARG00000005191; D150; cb1079; hm:zeh1173; hm:zeh1364; wu:fj67b02; ahcy
Description S-adenosylhomocysteine hydrolase
GenomicLocation chromosome 6 49877781-49917954 forward strand
ExternalIDs Entrez:387530; EMBL:BC044200; UniGene:76562; ZFIN:ZDB-GENE-031219-6;
TranscriptID ENSDART:ENSDART00000018523
mRNA NCBI:NM_199218
GeneDescription The gene S-adenosylhomocysteine hydrolase encodes for a protein adenosylhomocysteine hydrolase (AHCY), an important enzyme for metabolizing S-adenosyl-l-homocysteine, the by-product of S-adenosyl-l-homomethionine-dependent methylation.
GeneFunction Cooper BJ et al. (2006) identified two zebrafish AHCYL1 orthologs (zAHCYL1A and -B) by bioinformatics and reverse transcription-PCR. Quantitative reverse transcription-PCR showed that zAHCYL1A and -B mRNA expression was regulated differently from the other AHCY-like protein zAHCYL2 and zAHCY during zebrafish embryogenesis. Human and zebrafish AHCYL1A mRNA injection into zebrafish embryos induced dorsalized morphologies that were similar to those obtained by depleting intracellular calcium with thapsigargin. Their data suggested that AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release.
GeneCloning The gene is contained in a BAC clone DKEY-16N21 (Vector: pIndigoBAC-536).
GeneStructure The gene encodes for a single transcript ENSDART00000018523 which consists of 10 exons and is 1,922 bps in length. The protein product ENSDARP00000002844 consists of 433 residues.
Protein ENSDARP00000002844
ProteinDomainandFamilies has domain InterPro:IPR000043; InterPro:IPR015878;
Motifs has motif Prosite:PS00738; PFAM:PF00670; PFAM:PF05221;
Expression ArrayExpress:ENSDARG00000005191;
GeneOntology GO:0006730; GO:0004013; GO:0016787;
Orthologs Entrez:191;
VariationAndRepeats RSID:rs40634938; RSID:rs41017906; RSID:rs41220292; RSID:rs40644863; RSID:rs40659418; RSID:rs40957134; RSID:rs40656686; RSID:rs40659419; RSID:rs40647217; RSID:rs40654534;
DisordersAndMutations The morpholino antisense oligonucleotides targeted against zAHCYL1A and zAHCYL2 have the following sequence respectively- MO1 A(5'-TGGCATCCTCGCCACAGTCTGTCAT-3') and MO1 B(5'-CATGGTTCATGTTCCCTGTGTGTGT-3'). ZFINID:ZDB-GENO-090428-1; ZFINID:ZDB-GENO-050816-6;
RelatedPubMedArticles Cooper, BJ; Key, B; Carter, A; Angel, NZ; Hart, DN; Kato, M. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. J Biol Chem. 281(32):22471-84. PMID:16754674 .NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r2 - 2013-07-06 - DivyaJagga
 
This site is powered by the TWiki collaboration platform Powered by PerlCopyright © 2008-2017 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding TWiki? Send feedback

mersin escort bayan adana escort bayan izmit escort ankara escort bursa escort