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alcohol dehydrogenase 5

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GeneName adh5
Aliases ENSDARG:ENSDARG00000080010; ADH3, wu:fb60b11
Description alcohol dehydrogenase 5
GenomicLocation chromosome 14 45834134-45846283 reverse strand
ExternalIDs Entrez:116517; EMBL:AF399909; UniGene:150302; ZFIN:ZDB-GENE-011003-1;
TranscriptID ENSDART:ENSDART00000108825
mRNA NCBI:NM_131849
GeneDescription This gene encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Functionally, Adh5 is a glutathione-dependent formaldehyde dehydrogenase.
GeneFunction Dasmahapatra et al. (2005) reported that adh5 is expressed during early development and thus it may play a key role in ethanol metabolism during early development (048 h) and the ethanol-induced cardiovascular abnormalities may be the result of acetaldehyde formation by ADH5 rather than direct effect of ethanol.


GeneStructure This gene encodes single transcript

(ENSDART00000108825) consists of 9 exons and is 1,322 bps in length.The protein product (ENSDARP00000099464) consists of 376 residues.
Protein ENSDARP00000099464
ProteinDomainandFamilies has domain InterPro:IPR002328; InterPro:IPR014183; InterPro:IPR002085; InterPro:IPR013154; InterPro:IPR013149;
Motifs has motif Prosite:PS00059; PFAM:PF00107; PFAM:PF08240;
Expression ArrayExpress:ENSDARG00000040874
GeneOntology GO:0006829; GO:0016491; GO:0046872; GO:0008270; GO:0016491; GO:0046872;
Orthologs Entrez:128;
VariationAndRepeats RSID:rs40664221; RSID:rs40677801; RSID:rs40830944;

RelatedPubMedArticles Dasmahapatra, A, K.; Wang, X,; Haasch, M, L.: Expression of Adh8 mRNA is developmentally regulated in Japanese medaka (Oryzias latipes). Comp Biochem Physiol B Biochem Mol Biol.;140(4):657-64. 2005. PMID:15763521
NCBI Resource Coordinators.: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 41(Database issue):D8-D20. 2013. PMID:23193264
Kersey, P. J.; Allen, J. E.; Christensen, M.; et al.: Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res. 2013. PMID:24163254
Sigrist, C. J. A.; de, Castro, E; Cerutti, L; Cuche, B. A.; Hulo, N.; Bridge, A.; Bougueleret, L. Xenarios, I.: New and continuing developments at PROSITE. Nucleic Acids Res. doi: 10.1093/nar/gks1067. 2012. PMID:23161676
Punta, M.; Coggill, P. C.; Eberhardt, et al.: The Pfam protein families database. Nucleic Acids Res. 40(Database Issue):D290-D301. 2012. PMID:22127870
Hunter, S.; Jones P.; Mitchell A.; et al.: Interpro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. doi: 10.1093/nar/gkr948. 2011. PMID:22096229
Carbon, S.; Ireland, A.; Mungall, C. J.; Shu, S.; Marshall, B.; Lewis, S.; AMIGO Hub; Web Presence Working Group.: AMIGO: online access to ontology and annotation data. Bioinformatics. 25(2):288-9. 2009. PMID:19033274
Ashburner, M.; Ball, C. A.; Blake, J. A.; et al. The Gene Ontology Consortium.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1):25-9. 2000. PMID:10802651
Sherry, S. T.; Ward, M. H.; Kholodov, M.; Baker, J.; Phan, L.; Smigielski, E. M.; Sirotkin, K.: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 1;29(1):308-11. 2001. PMID:11125122
Bradford, Y.; Conlin, T.; Dunn, N.; et al.: ZFIN: enhancements and updates to the zebrafish model organism database. Nucleic Acids Res. 39(suppl 1):D822-D829. 2011. PMID:21036866
Kapushesky, M.; Adamusiak, T.; Burdett, T.; et al.: Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Res. 40(Database isue):D1077-81. 2012. PMID:22064864

Web resources:
NCBI: http://www.ncbi.nlm.nih.gov/
PFAM: http://pfam.sanger.ac.uk/
PROSITE: http://prosite.expasy.org/
Interpro: http://www.ebi.ac.uk/interpro/
ZFIN: http://zfin.org/
Expression Atlas (EMBL): http://www.ebi.ac.uk/gxa/
Ensembl: http://asia.ensembl.org/Danio_rerio/
Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine.: http://www.ncbi.nlm.nih.gov/SNP/
PRINTS from Genomenet: http://www.genome.jp/
European Nucleotide Archive: http://www.ebi.ac.uk/ena/home
UNIGENE: http://www.ncbi.nlm.nih.gov/unigene/
AMIGO Gene Ontology: http://amigo.geneontology.org
Topic revision: r7 - 2012-01-01 - MeghnaSingh
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