LOVD OAS1 homepage

General information
Gene name 2'-5'-oligoadenylate synthetase 1, 40/46kDa
Gene symbol OAS1
Chromosome Location 12q24.2
Database location genome.igib.res.in/PGx
Curator Ruchika Sahajpal
Date of creation June 18, 2012
Last update June 18, 2012
Version OAS1 120618
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Total number of unique DNA variants reported 0
Total number of individuals with variant(s) 0
Total number of variants reported 0
NOTE Also known as: OIAS; IFI-4; OIASI
Summary: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Links to other resources
Homepage http://genome.igib.res.in
External link #1 Ensembl
External link #2 UCSC
External link #3 Genecards
Entrez Gene 4938
HGMD OAS1
GeneTests OAS1